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ICAR SINONASAL TUMORS

TABLE XII.1 Evidence surrounding margin analysis for sinonasal tumors.

Clinical endpoints

Study

Year LOE Study design Study groups

Conclusions

Adenocarcinoma Bignami et al. 363 2018 4

Retrospective case series

Patients with

1. 5-year OS 2. 5-year DSS 3. 5-year RFS

1. 5-year OS and DSS were 100% for NM versus 50% ± 3.54% for PM 2. NM group had a better RFS 3. Margins were an independent prognostic factor for OS Margins status associated with OS andDSS

non-ITAC with PM ( n = 2) versus NM ( n = 20)

Schreiber et al. 374

1. OS 2. DFS 3. RFS

2018 4

Case–control

Patients who

underwent either uEEATC( n = 27) or bEEATC( n = 27, control) for ITAC withPM( n = 3) versusNM( n = 51) versusNM( n = 23) Patients with SCC or adenocarcinoma of the maxillary sinus withPM( n = 20) versusNM( n = 44) Patients with ITAC withPM( n = 7)

Antognoni et al. 362

2015 4

Retrospective case series

1. 5-year OS 2. 5-year DFS

Margin status was significantly associated with 5-year OS and 5-yearDFS LR detected in 15 out of 20 patients with PM versus one out of 44 patients with NM

Hordijk and Brons 389

LR

1985 4

Retrospective case series

Adenoid cystic carcinoma Shayet al. 375

OS

MS was a predictor of OS

Patients with ACC

2020 4

Retrospective database review (NCDB) Retrospective case series

withPM( n = 140) versusNM( n = 381)

Volpi et al. 106

2019 4

Patients with ACC

5-year OS and DSS

5-year OS and DSS were both 94% ± 6% for NM versus 42% ± 3%forPM

treated with radical surgical intent with PM( n = 7) versus NM( n = 27)

Trope et al. 376

OS

PM were associated with worse OS

Patients with ACC

2019 4

Retrospective database review (NCDB) Retrospective case series

withPM( n = 259) versusNM( n = 225)

Mays et al. 398

2018 4

Patients with ACC

1. OS 2. DFS

MS was not associated with OS or DFS

treated with curative intent with PM ( n = 40) versus NM ( n = 38)

Seong et al. 399

1. DFS 2. DSS

PM did not significantly affect DSS orDFS

2014 4

Retrospective case series

Patients with ACC treated with

surgery ± adjuvant therapy with PM ( n = 19) versus NM ( n = 5)

Michel et al. 408

2013 4

Retrospective case series

Patients with ACC

Survival

MS was not significantly associated with OS or DFS

withPM( n = 11) versusNM( n = 6)

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