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100

KUANetal.

TABLE XII.1 (Continued)

Clinical endpoints

Study

Year LOE Study design Study groups

Conclusions

Resto et al. 371

LRC, DFS, 5-year OS,DMF

1. MS/extent of surgery did not impact LRC 2. MS/extent of surgery did impact DFS, 5-year OS, and DMF

2008 3

Retrospective cohort

Patients with locally advanced SNM treated with surgery with complete resection (NM = 20), STR(PM = 50), and biopsy only (PM = 32) followed byproton + photon beamRT Patients with SNM who underwent CFRwithPM ( n = 95) versus NM ( n = 234) Patients with non-SCC malignancies with PM( n = 263) versus NM( n = 311)

Ganly et al. 174

2005 3

Retrospective cohort

1. 5-year DSS 2. 5-year OS 3. 5-year RFS

MS was an independent predictor of OSandDSS

1. Neoadjuvant therapy was associated with a lower prevalence of PM 2. Patients with SNUC had the highest reduction in the risk of PM 3. NM was associated with improved OS 1. MS impacted survival in SS 2. Survival analysis demonstrated significantly worse OS outcomes for SS patients with PM

1. Impact of

Al-Qurayshi et al. 360

2022 4

Retrospective database review (NCDB)

neoadjuvant therapyon MS

2. OS

Lehrich et al. 378

2021

4

Retrospective database review (NCDB)

Patients with SNM who underwent either primary

OS

surgery ( n = 2804; PM = 826, NM = 1552) versus salvage surgery ( n = 207; PM = 54, NM = 115)

OS

MS was not found to be a predictor of mortality

Povolotskiy et al. 315

Patients with non-SCC malignancies who underwent definitive primary surgery either EEA ( n = 673; PM = 148, NM = 303) orOR ( n = 922; PM = 258, NM = 443) Patients with non-SCC malignancies who underwent

2020 4

Retrospective database review (NCDB)

Fuet al. 380

2018 4

Retrospective case series

Margin control

Neoadjuvant RT significantly reduced the risk of PM even after controlling for T stage and treatment (OR + EEA vs. EEA) factors

neoadjuvant RT + surgery ( n = 23) versus surgery + RT ( n = 61)

(Continues)