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99

ICAR SINONASAL TUMORS

TABLE XII.1 (Continued)

Clinical endpoints

Study

Year LOE Study design Study groups

Conclusions

One-, 2-, 3-, and 5-yearOS

1. 1-year OS rates were 87%, 72%, and 47% for NM, PM, and no surgery, respectively 2. 2-year OS rates were 72%, 36%, and 16% 3. 3-year OS rates were 55%, 16%, and8% 4. Only patients in NM group were alive at 5 years (39%) 5. Propensity score matching demonstrated a difference between NM and PM 1. Improved survival was associated with surgical resection only when NM 2. MS was a predictor of survival 1. DMFS reduced in patients with PM 2. OS was negatively influenced by PM 3. PM status was associated with decreased DMFS NM associated with improved survival

Patients with SNMM withPM( n = 120), no surgery ( n = 63), versusNM( n = 263)

Elsamna et al. 365

2021

4

Retrospective database review (NCDB)

Ganti et al. 366

2020 4

Retrospective database review (NCDB) Retrospective case series

Patients with SNMM withPM( n = 355) versusNM( n = 812) Patients with SNMM withPM( n = 11) versusNM( n = 15)

OS

Caspers et al. 364

1. DMFS 2. OS

2018 4

Konuthula et al. 368

2017 4

Retrospective database review (NCDB) Retrospective case series

Patients with SNMM withPM( n = 127)

5-year survival

versusNM( n = 300)

3-yearOS

MS did not impact 3-year OS

Vandenhende et al. 402

2012 4

Patients with SNMM treated with surgical curative intent with PM( n = 4) versus NM( n = 12) Patients with SNMM who underwent primary surgery withPM( n = 12) versusNM( n = 44) Patients with SNMM withPM( n = 18) versusNM( n = 13) Patients with SNMM withPM( n = 5) versusNM( n = 8)

Moreno et al. 232

2010 4

Retrospective case series

1. Two- and 5-yearOS 2. LR

1. Nonsignificant difference in 2-year (NM 64% versus PM 42%) and 5-year (NM 44% versus PM 25%) survival 2. Nonsignificant increase in LR in PM 42% versus NM 20% MS was not a significant predictor of LR, RR, or DM

Bachar et al. 400

2008 4 b

1. LR 2. RR 3. DM 1. OS 2. LRC

Retrospective cohort

Kingdom and Kaplan 401

1995 4

Retrospective case series

NM do not appear to predict a better OS or LRC

Mixed tumor Dulguerov et al. 22

2001 2

Systematic reviewof

Patients with SNM ( n = 156) with PM versusNM

Two- and 5-year actuarial LRC

Two- and 5-year actuarial LRC rates were 59% ± 9%and45% ± 9%for PM versus 70% ± 7%and 65% ± 7%forNM (Continues)

retrospective case series