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104

KUANetal.

TABLE XII.1 (Continued)

Clinical endpoints 1. Factors

Study

Year LOE Study design Study groups

Conclusions

Torabi et al. 241

1. PM status was associated with treatment at LVF, T stage ≥ 3, poorly differentiated tumor, and location in ethmoid sinuses 2. PM associated with decreased OS versus NM 3. No difference in PM status between EEA versus open surgery micro-PM improved OS over nonsurgical treatment, while macro-PM did not 2. Macro-PM were significantly higher when primary tumor was in the primary surgery versus NC and advanced T classification 1. Patients with NM had improved survival compared to PM 2. Micro-PM versus NM, and macro-PM versus NM were associated with worse survival 1. The rate of PM between EEA and open surgery was comparable except greater PM rate in EEA for IVB tumors 2. MS was associated with poorer survival Increasing T stage less likely to have NM (T3 and T4), neoadjuvant CRT associated with increased likelihood of achieving NM 1. Propensity-score-matched results showed NM and

Patients with SCC with PM( n = 807) versus NM( n = 2161)

2020 4

Retrospective database review (NCDB)

associated withPM

2. survival

Jafari et al. 161

2019 4

Retrospective database review (NCDB)

Patients with SCC with micro-PM( n = 511) versus macro-PM ( n = 521) versus NM ( n = 2289)

1. Factors

associated withPM

2. OS

Cracchiolo et al. 160

5-yearOS

Patients with SCC with PM( n = 475) versus NM( p = 1212)

2018 4

Retrospective database review (NCDB) Retrospective database review (NCDB)

Kilic et al. 135

2018 4

Patients with SCC

1. MS 2. OS

treated with EEA ( n = 353; PM = 74, NM = = 169) versus OR( n = 1130;

PM = 267, NM = 749)

Robin et al. 159

Likelihood of

Patients in the NCDB with SCC who underwent surgery with or without adjuvant therapy withPM( n = 537) Patients treated for IP-SCC at two institutions with PM ( n = 2) versus NM ( n = 32) Patients with SCC with PM( n = 5) versus NM( n = 22) versusNM ( n = 1422)

2017 4

Retrospective database review (NCDB)

achieving NM

Karligkiotis et al. 247

2016 4

Retrospective case series

OS

MS was not associated with OS

1. LRC and DFS with NM were 74% at 5 years versus 0% at 5 years for PM 2. 5-year OS was 93% in NM versus 0%PM (Continues)

1. LRC 2. DFS 3. 5-year OS

deAlmeida et al. 130

2015 4

Retrospective case series