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KUANetal.

TABLE XIV.1 (Continued)

Clinical endpoints 5-year LPFS

Study

Year LOE Study design Study groups

Conclusion

Swain et al. 482

LPFS51%

2021

4

Retrospective case series

ACC at a single

institution (SNM n = 13)

Tinget al. 483

2021

4

Retrospective case series

SNM at a single

Ocular and

High-dose EBRT for inoperable maxillary sinus tumors can lead to a wide array of severe ocular/periocular complications Surgery combined with RT with or without chemotherapy resulted in significantly better OS (84.4 vs. 50.6%, 84.4 vs. 37.5%) compared to surgery alone and RT alone 1. LPFS90% 2. OS90% 3. Severe late toxicities were infrequent (11.5%) Smaller disease burden showing improved oncologic control 1. OS57% 2. 5-year PFS and OS were similar betweenRT ± surgery In IMRT era, no differences in OS, PFS, or LFRS between CRT ± surgery 76 (41%) of patients relapsed, and the majority were in the involved primary site (76%) 1. PFS63% 2. OS55%

institution ( n = 7)

periocular complications following EBRT

Zenget al. 484

2021

4

Retrospective case series

ONB at a single

OS

institution ( n = 64)

Chenet al. 485

2021

4

Retrospective case series

SNM at a single

1. 5-year PFS 2. 5-year OS

institution ( n = 49, helical tomotherapy)

Baoet al. 486

2020 4

Retrospective case series

ONB at a single

1. 3-year LPFS 2. 3-year OS

institution ( n = 52)

Ferella et al. 487

2020 4

Retrospective case series

SNM at a single

Tumor volume association with PFS and OS

institution ( n = 34)

Li et al. 164

1. 5-year OS

2020 4

Retrospective case series

SNM at a single

institution ( n = 93; IMRT n = 38, 3DCRT n = 55) institution ( n = 37) comparing CRT ± surgery multi-institutional national database ( n = 184) SNM at two centers in Denmark ( n = 27) ONB at a single SNMacross

Liuet al. 488

2020 4

Retrospective case series

1. 5-year OS 2. 5-year PFS 3. 5-year LRFS

Sharma et al. 489

Patterns of failure

2020 4

Retrospective case series

Sharma et al. 490

2020 4

Retrospective case series

Cerebral toxicity Clinically significant cognitive

impairment was present in more than one third of the participants,

and several dose–response associations were present

Sharma et al. 491

2020 4

Retrospective case series

SNM at two centers in Denmark ( n = 27)

Late toxicity

Late toxicity after RT was substantial in all examined organs, with dose–response associations between visual acuity impairment and the optic nerve (Continues)