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KUANetal.

TABLE XIV.2 (Continued)

Clinical endpoints

Study

Year LOE Study design Study groups

Conclusion

Yuet al. 524

1. 93%/34% 2. 77%/32% 3. 100%/76% 4. re-RT was associated with inferior FFLR 5. Late toxicities occurred in 15% of patients, with no grade 3 or + toxicities 6. No patients developed vision loss or symptomatic brain necrosis 1. PFS 80%/65%/39% 2. OS 100%/86%/76% 3. Late adverse events of grade 3–4 were seen in six patients (ipsilateral visual impairment, 3; bilateral visual impairment, 1; liquorrhea, 1; cataract, 1) 1. PFS63% 2. CCS70% 3. OS68% 4. Patients who underwent GTR had a 90% LC rate 1. LC80% 2. OS47% 3. Nine grade 3 and 6 grade 4 toxicities, and no grade 5 toxicities 1. OS88% 2. Two cases of grade 2 retinopathy and one case of grade 3 optic neuropathy LC was achieved in 43% of patients 1. LC60% 2. OS60%

1. 3-year FFLR (local-reg) 2. 3-year FFDP 3. 3-year OS

2019 4

Retrospective case series

SNM

multi-institutional of denovo ( n = 42) or re-irradiation ( n = 27)

Dautruche et al. 525

2018 4

Retrospective case series

ACC at single

1. 3-year LC 2. 3-year OS

institution (SNM n = 8)

Nakamura et al. 526

2017 4

Retrospective case series

ONB at single

1. 5-year PFS A/B/C 2. 5-year OS A/B/C Stratified by Kadish stage 1. 3-year PFS 2. 3-year CCS 3. 3-year OS

institution ( n = 42)

Dagan et al. 527

2016 4

Retrospective case series

SNM at single

institution ( n = 84)

Russo et al. 528

2016 4

Retrospective case series

SNM at single

1. 5-year LC 2. 5-year OS 3. Toxicity

institution ( n = 44)

Lucas et al. 529

1. 4-year OS

2015 4

Retrospective case series

Pediatric ONB at single institution ( n = 8)

Saito et al. 530

2015 4

Retrospective case series Retrospective case series

SNM at single

LC

institution ( n = 7)

Zenda et al. 531

2015 4

SNM at single

1. 5-year PFS 2. 5-year OS 3. 5-year toxicities 1. 5-year DFS 2. 5-year OS

1. PFS45% 2. OS64% 3. Tox 19%

institution primary ( n = 90)

Herr et al. 532

2014 4

Retrospective case series

ONB at single

1. LC86% 2. OS95% 3. High incidence of regional metastases warrants strong consideration for ENI

institution ( n = 22)

Fukumitsu et al. 533

2012 4

Retrospective case series

SNM at single institution

1. 5-year LC 2. 5-year OS

1. LC18% 2. OS 16%

(Unresectable n = 17)

Okano et al. 534

2012 4

Retrospective case series

SNM at single

1. 5-year PFS 2. 5-year OS

1. PFS34% 2. OS76%

institution ( n = 13)

(Continues)