xRead - Nasal Obstruction (September 2024) Full Articles

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KUANetal.

TABLE XIV.4 Evidence surrounding carbon ion therapy in treatment of sinonasal tumors.

Clinical endpoints 1. 3-year LC 2. 3-year OS

Study

Year LOE Study design Study groups

Conclusion

Zhang et al. 474

1. LC80% 2. OS75% 3. LC and OS were significantly higher after CIRT than PBT or IMRT 4. No significant difference between PRT and IMRT for OS and LC was observed 1. LRC 0.76 (0.68–0.86) 2. DFS 0.80 (0.67–0.95) 3. OS 0.72 (0.58–0.90) 4. Subgroup analysis comparing CPT with photons, CPT showed significantly higher 5-year DFS, OS, and LRC at longest follow-up

44 cohorts comparing 2282 patients treated with CIRT, PBT, or IMRT (IMRT, n = 911)

2020 2

Systematic

reviewand meta analysis

Patel et al. 458

2014 2

Systematic

SNM patients

E1 .v eLnot nr ga et es st : follow-up LRC 2. 5-year DFS 3. 5-year OS

reviewand meta analysis

undergoing either particle or photon radiotherapy ( n = 1472; CPT therapy n = 58 for DFSand n = 146 for OS)

Kuboet al. 549

1. G1 46% 2. G2 7%

Incidences of

2019 3

Prospective

SNM at single

Grade 1 and 2 nasolacrimal duct obstructions

case series

institution (SNM n = 15)

Jensen et al. 550

2015 3

Prospective

Salivary gland tumors at single institution

1. 3-year LC 2. 3-year PFS 3. 3-year OS

1. LC82% 2. PFS58% 3. OS78% 4. No significant difference could be shown regarding resection status

case series

(SNM, n = 18, IMRT + CIRT)

Musha et al. 551

1. LC75% 2. PFS53% 3. OS81% 4. Acute grade 3 radiation

1. 5-year LC 2. 5-year PFS 3. 5-year OS 4. Toxicity

2022 4

Retrospective case series

SNM at single

institution (SNM n = 18)

mucositis was seen in eight patients, and late grade 4 adverse events were observed, including two cases of visual loss and one case of brain necrosis

Bhattacharyya et al. 552

2020 4

Retrospective case series

SNM at single

Oronasal fistula 37 developed small localized fistula; however, none were of grade 3severity

institution ( n = 50; IMRT + CIRT)

1. 51% 2. 63%

Hagiwara et al. 553

2020 4

Retrospective case series

SNM at single

1. 5-year LC 2. 5-year OS 3. Toxicity

institution ( n = 22)

3. Grade 4 visual impairment and grade 4 brain necrosis were seen in six and one patient, respectively 1. LPFS83% 2. PFS66% 3. OS82% 4. Late toxicity occurred in 22 (19.8%) patients, but only four (3.6%) patients experienced grades 3–4 late toxicity

Huet al. 554

2020 4

Retrospective case series

SNM at single

1. 2-year LPFS 2. 2-year PFS 3. 2-year OS 4. Toxicity

institution (PBT n = 4, CIRT n = 70, CIRT + PBT n = 37)

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