xRead - Nasal Obstruction (September 2024) Full Articles

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129

ICAR SINONASAL TUMORS

TABLE XIV.4 (Continued)

Clinical endpoints

Study

Year LOE Study design Study groups

Conclusion 1. LC82% 2. PFS70% 3. OS77%

Huet al. 555

1. 3-year LC 2. 3-year PFS 3. 3-year OS 1. 3-year LC RT 2. 3-year LC postopRT 3. Toxicity

2020 4

Retrospective case series

ACC SNM at single institution (PBT

n = 3, CIRT n = 17, CIRT + PBT n = 18)

Akbaba et al. 556

2019 4

Retrospective case series

ACC SNM at single

1. LC79% 2. LC82% 3. Worse late toxicity observed for postoperative RT 17% versus 6% late grade 3 toxicity Experimental treatment increased overall costs by € 18,076 (€13,416–€22,922) at a mean survival benefit of 0.86 years. Despite improved local control, following costs were also increased in the experimental treatment ICER was estimated to be 26,863 €/LY 1. LC84% 2. OS80% 3. 17% of patients developed grade 3 and 4 toxicities, of which visual impairment was the most common including ipsilateral optic nerve disorder ( n = 2) and ipsilateral retinopathy ( n = 1) 1. LC68% 2. PFS44% 3. OS74% 4. 43 patients (15%) experienced grade ≥ 3 late toxicity, of which osteonecrosis of the jaw bone was the most common 5. Two patients treated for nasopharyngeal ACC died from a bleeding ulcer at the tumor site (grade 5 toxicity) 1. LC50% 2. PFS35% 3. OS42% 4. Late toxicities of grade ≥ 3 occurred in 13 patients (22%) 1. PFS81% 2. OS 100% 1. LC83% 2. OS88% 3. Grade 4 late toxicity was observed in three patients,

institution ( n = 227, IMRT + CIRT)

ICER

Jensenand Debus 470

2019 4

Cost-effective analysis

ACC at a single

institute (IMRT n = 37, IMRT + CIRT n = 58)

Kotoet al. 472

2018 4

Retrospective case series

SNM across four

1. 2-year LC 2. 2-year OS 3. Toxicity

carbon centers in Japan ( n = 458)

Liermann et al. 557

1. 4-year PFS 2. 4-year OS

2018 4

Retrospective case series

ONB at single

institution (CIRT n = 4, + -photons n = 8)

Suefuji et al. 558

2018 4

Retrospective case series

ONB at single

1. 3-year LC 2. 3-year OS

institution ( n = 21)

Sulaiman et al. 560

1. 5-year LC 2. 5-year PFS 3. 5-year OS

2018 4

Retrospective case series

ACCat four

institutions (SNM n = 122)

Toyomasu et al. 559

2018 4

Retrospective case series

SNM at single

1. 5-year LC 2. 5-year PFS 3. 5-year OS

institution ( n = 59, PT n = 38, CIRT n = 21)

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