xRead - Nasal Obstruction (September 2024) Full Articles
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ICAR SINONASAL TUMORS
TABLE XIV.4 (Continued)
Clinical endpoints
Study
Year LOE Study design Study groups
Conclusion 1. LC82% 2. PFS70% 3. OS77%
Huet al. 555
1. 3-year LC 2. 3-year PFS 3. 3-year OS 1. 3-year LC RT 2. 3-year LC postopRT 3. Toxicity
2020 4
Retrospective case series
ACC SNM at single institution (PBT
n = 3, CIRT n = 17, CIRT + PBT n = 18)
Akbaba et al. 556
2019 4
Retrospective case series
ACC SNM at single
1. LC79% 2. LC82% 3. Worse late toxicity observed for postoperative RT 17% versus 6% late grade 3 toxicity Experimental treatment increased overall costs by € 18,076 (€13,416–€22,922) at a mean survival benefit of 0.86 years. Despite improved local control, following costs were also increased in the experimental treatment ICER was estimated to be 26,863 €/LY 1. LC84% 2. OS80% 3. 17% of patients developed grade 3 and 4 toxicities, of which visual impairment was the most common including ipsilateral optic nerve disorder ( n = 2) and ipsilateral retinopathy ( n = 1) 1. LC68% 2. PFS44% 3. OS74% 4. 43 patients (15%) experienced grade ≥ 3 late toxicity, of which osteonecrosis of the jaw bone was the most common 5. Two patients treated for nasopharyngeal ACC died from a bleeding ulcer at the tumor site (grade 5 toxicity) 1. LC50% 2. PFS35% 3. OS42% 4. Late toxicities of grade ≥ 3 occurred in 13 patients (22%) 1. PFS81% 2. OS 100% 1. LC83% 2. OS88% 3. Grade 4 late toxicity was observed in three patients,
institution ( n = 227, IMRT + CIRT)
ICER
Jensenand Debus 470
2019 4
Cost-effective analysis
ACC at a single
institute (IMRT n = 37, IMRT + CIRT n = 58)
Kotoet al. 472
2018 4
Retrospective case series
SNM across four
1. 2-year LC 2. 2-year OS 3. Toxicity
carbon centers in Japan ( n = 458)
Liermann et al. 557
1. 4-year PFS 2. 4-year OS
2018 4
Retrospective case series
ONB at single
institution (CIRT n = 4, + -photons n = 8)
Suefuji et al. 558
2018 4
Retrospective case series
ONB at single
1. 3-year LC 2. 3-year OS
institution ( n = 21)
Sulaiman et al. 560
1. 5-year LC 2. 5-year PFS 3. 5-year OS
2018 4
Retrospective case series
ACCat four
institutions (SNM n = 122)
Toyomasu et al. 559
2018 4
Retrospective case series
SNM at single
1. 5-year LC 2. 5-year PFS 3. 5-year OS
institution ( n = 59, PT n = 38, CIRT n = 21)
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