xRead - Nasal Obstruction (September 2024) Full Articles

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ICAR SINONASAL TUMORS

TABLE XVI.2 (Continued)

Clinical endpoints

Study

Year LOE Study design Study groups

Conclusion

1. Risk factors for recurrence of sinonasal papilloma include young at initial diagnosis and incomplete tumor resection 2. HPV infection may play a role in

Pähler vor der

2020 3

Retrospective cohort

100 patients treated for sinonasal papilloma

1. Identify and assess potential

Holte et al. 730

clinical and risk factors for

the development and/or progression of sinonasal papilloma

development of sinonasal papilloma 2. Identify and assess potential clinical and biological risk factors for recurrence of low-risk HPV, high-risk HPV, and p16 positivity 2. Relationship between EGFR mutations andHPV status sinonasal papilloma 1. Rates of

Mehrad et al. 666

2020 3

Retrospective cohort

44 patients with IP

1. All samples negative for p16 and high-risk HPV 2. Low-risk HPV subtypes mutually exclusive with EGFR mutations 3. Low-risk HPV positivity and

EGFR mutations may be alternate mechanisms of pathogenesis

Cabal et al. 669

1. Activation of EGFR through phosphorylation is important in the pathogenesis of this pathway 2. EGFR inhibitors are a potential treatment pathway for some SNSCC patients.

1. Determine

2020 3

Retrospective cohort

55 patients with IP, 14 patients with SNSCC associated with IP, and 60 SNSCCnot associated with IP

the presence of EGFR gene mutation and protein expression the presence ofHPV infection the presence ofKRAS mutation

2. Determine

3. Determine

Elliot et al. 751

2019 3

Retrospective cohort

98 patients diagnosed with IP

Determine the presence of stathmin, EGFR, and HPV

1. Higher stathmin correlated with dysplasia and earlier recurrences 2. No association between EGFR and recurrence or dysplasia

(Continues)

recent evidence also suggests that low-risk HPV is an independent risk factor for malignant transformation of IP. 659,666–668 Differentiating de novo sinonasal SCC from malignant conversion of IP can present a diagnostic dilemma, as

there is increasing recognition of high-risk HPV as a primary etiologic factor for SNM, and high-risk HPV associated sinonasal SCC may show morphologic overlap with IPs and associated sinonasal carcinomas. 661,669–672 Indeed, similar to HPV-associated oropharyngeal SCC,