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TABLE II. MINORS Scores for Included Studies by Criteria.

Follow-up Period Appropriate toAimof Study

Endpoints Appropriate toAimof Study

Unbiased Assessment of the Study Endpoint

Clearly Stated Aim

Inclusion of Consecutive Patients

Prospective Collection of Data

Loss to Follow up<5%

Prospective Calculation of Study Size

MINORS Score

Author

Year

Amer

2017 2014 2021 2021

2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2

2 2 1 1 0 1 2 2 2 1 1 2 2 2 2 2 2 2 2 1 2 2 2 2 2 2 2 2

2 2 0 0 2 2 2 2 2 2 2 2 2 2 0 2 2 2 0 0 2 2 2 2 2 2 2 2

2 2 2 1 2 2 2 2 1 2 2 2 2 2 2 2 2 2 1 2 2 2 2 2 2 2 2 2

1 1 1 1 1 1 1 1 2 1 2 2 1 1 1 1 2 2 1 1 2 1 2 1 1 1 1 2

1 1 2 1 1 2 1 1 1 1 1 1 1 2 2 1 1 1 1 1 1 1 1 1 1 1 2 1

2 2 2 2 1 2 2 1 2 2 2 2 2 2 2 2 2 2 2 2 2 2 1 2 2 2 1 2

2 2 0 0 1 2 2 1 2 0 2 2 1 0 0 2 2 1 0 0 2 1 1 2 2 2 2 2

14 14 10

Lachanas

Askakal

Awan

8 8

Balsevicius 2020 Bonaparte 2018

14 14 12 14 11 14 15 13 13 11 14 15 14 15 13 13 14 14 14 14 15 9 9

Cantone

2018 2021

D ą browska Bie n

Dagistan

2021 2017 2019 2021 2019 2014 2016 2015 2014 2020 2020 2012 2012 2022 2004 2021

Kim

Garzaro

Ghosh

Gillman

Gökçe

Hsu, H.C 2017

Karahatay

Kumar

Larrosa

Law

Mehel

Mondina

Kahveci

Seden

Stewart

Taylan

Valsamidis 2019 Valsamidis 2018

Yazici

2015

Note : Score per Criterion: 0, not reported; 1, reported but inadequate; 2, reported and adequate. Ideal global score for noncomparative study is 16. Abbreviation: MINORS, methodological index for non-randomized studies.

Results are reported in the forest plot presented in Figure 3. The pooled MD in NOSE score at 3-months follow-up compared to baseline was 53.7 ( n = 980, 95% CI: 62.2 to 45.2). Substantial between-study heterogeneity (Q = 809, p < 0.05) was measured I 2 = 98.5% (95% CI: 98.1% – 98.8%) and τ 2 = 186.1 (95% CI: 91.8 – 528.6). Global results are reported in the forest plot presented in Figure 4A. The pooled MD in NOSE score at 6-months follow-up compared to baseline was 48.8 ( n = 1730, 95% CI: 54.6 to 42.9). Substantial between-study heterogeneity (Q = 560.4, p < 0.05) was measured I 2 = 96.8% (95% CI: 95.9% – 97.5%) and τ 2 = 130.4 (95% CI: 71.3 – 316.0). Global results are reported in the forest plot presented in Figure 4B. Baujat plot showing the studies contribution to the overall heterogeneity is shown in Figure 2B. The

The funnel plot generated for the 6 months follow-up analysis is shown in Figure 2A. Egger ’ s regression test showed a symmetric distribution of the points in the fun nel plot (Intercept = 1.39, p = 0.62), suggesting no obvi ous publication bias.

Septoplasty Outcomes According to NOSE Scores All the studies included in our analysis investigated the ef fi cacy of septal surgery using the validated self rating NOSE questionnaire. The pooled baseline NOSE mean score was 68.1 ( n = 2577, 95% CI: 64.3 – 71.9) based on random effect meta-analysis. Substantial between-study heterogeneity (Q = 1440.4, p < 0.05) was measured I 2 = 98.1% (95% CI: 97.8% – 98.4%) and τ 2 = 134.3 (95% CI: 64.7 – 219.6).

Laryngoscope 133: December 2023

Alessandri-Bonetti et al.: NOSE Score After Septoplasty 3241