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15314995, 2023, 12, Downloaded from https://onlinelibrary.wiley.com/doi/10.1002/lary.30684 by Stanford University, Wiley Online Library on [01/07/2024]. See the Terms and Conditions (https://onlinelibrary.wiley.com/terms-and-conditions) on Wiley Online Library for rules of use; OA articles are governed by the applicable Creative Commons License

Fig. 2. (A) Funnel plot for evaluation of publication bias in the 6 months follow-up analysis. (B) Baujat plot of studies ’ contribution to overall heterogeneity. [Color fi gure can be viewed in the online issue, which is available at www.laryngoscope.com.]

pooled MD in NOSE score at 6-months follow-up remov ing the main source of heterogeneity (Cantone et al. 46 ) demonstrated no signi fi cant difference in the NOSE score reduction (pooled MD: 50.3, 95% CI: 55.6 to 44.9). The pooled MD in NOSE score at 12-months follow up compared to baseline was 41.4 ( n = 223, 95% CI: 71.1 to 11.6). Substantial between-study heterogeneity (Q = 20.4, p < 0.05) was measured I 2 = 90.2% (95% CI: 74.0% – 96.3%) and τ 2 = 129.1 (95% CI: 25.3 – 1291.1).

Global results are reported in the forest plot presented in Figure 4C. In fl uence leave-one-out meta-analysis showed no in fl uential studies on the pooled MD in NOSE score at 3, 6, and 12 months follow-up. Subgroup analysis per formed based on the included studies level of evidence showed no difference between prospective ( n = 1281; pooledMD: 47.2, 95% CI: 55.7 to 38.8) and retrospec tive ( n = 449; pooled MD: 51.7, 95% CI: 58.8 to 44.5) studies at 6 months follow-up. The median MINORS

Fig. 3. Forest plot showing pooled baseline NOSE mean score and 95% con fi dence interval. [Color fi gure can be viewed in the online issue, which is available at www.laryngoscope.com.]

Laryngoscope 133: December 2023

Alessandri-Bonetti et al.: NOSE Score After Septoplasty

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