xRead - Nasal Obstruction (September 2024) Full Articles

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179

ICAR SINONASAL TUMORS

TABLE XIX.B.1 (Continued)

Clinical endpoints 1. Serum

Study

Year LOE Study design Study groups

Conclusions

Kubota et al. 960

1. Eight (33%) of the steroid-treated patients showed relapse 2. Serum rheumatoid factor was elevated in steroid-treated patients who relapsed at 6 months after discontinuation of treatment Intravenous corticosteroids are most advantageous for short-term symptomatic control and optic nerve dysfunction recovery

2013 4

Retrospective cohort

IgG4-ROD patients with ( n = 24) or without ( n = 6) corticosteroid treatment

rheumatoid factor 2. Recurrence

Bijlsma et al. 964

2011

4

Retrospective cohort

Patients with

1. Duration of oral prednisone 2. Symptom-free outcome 3. Complication

inflammatory pseudotumor treated with intravenous

corticosteroids plus oral steroids ( n = 12) and oral steroids only ( n = 15)

Chirapapaisan et al. 975

Three quarters of patients had unilateral disease; proptosis was most common presenting symptom Intraorbital corticosteroid should be considered an effective treatment for OP

2007 4

Retrospective case series

OP patients ( n = 49)

1. Demographic and clinical characteristics 2. Treatment outcomes

Leibovitch et al. 965

2007 4

Retrospective case series

Patients with clinical, radiologic, pathologic confirmation of OP treated with intra-orbital triamcinolone, repeated at 4 weeks if incomplete resolution ( n = 10)

Local and

systemic complications

Systemic steroid with slow taper should be considered first-line therapy for OP 1. Systemic involvement common when IgG4 ROD is bilateral or involving the lacrimal gland 2. Rituximab is a targeted therapy that may improve outcomes Histopathology is advocated as efficient manner of making diagnosis in orbital inflammatory disorders Empiric corticosteroid treatment and attention to responsiveness may obviate histopathologic diagnosis in orbital inflammatory disease

Yuenand

Clinical and treatment outcomes 1. Clinical features 2. Treatment outcomes

2003 4

Retrospective case series

Patients with

Rubin 962

idiopathic orbital inflammation ( n = 65)

Derzko

2017 5

Expert opinion N/A

Dzulynsky 945

Mombaerts et al. 976

2016 5

Expert opinion N/A

Expert opinion on utility of biopsy over corticosteroid in suspected OP Expert opinion on utilityof empiric corticosteroid in suspected orbital inflammation

Dagi Glass and Freitag 963

2016 5

Expert opinion N/A

(Continues)