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252

KUANetal.

TABLE XXIV.8 Other studies relevant to survival outcomes for ONB.

Clinical endpoints

Study

Year LOE Study design Study groups

Conclusions

Mays et al. 97

DFS

1. 5- and 10-year DFS were 89% and 78% 2. Resection of bone but not of dura/bulb affected DFS Socioeconomic status associated with lower 5-year DSS 1. Endoscopic cases had higher 5-year OS (81.9% vs. 75.6%, p = 0.030) 2. After multivariate regression, survival benefit to endoscopic surgery nonsignificant (HR 0.644; 95% CI: 0.392–1.058; p = 0.083) 10-year OS in the pediatric cohort was higher compared to the adult cohort (87% vs. 66%, p < 0.05) There was a long-term DSS decline of geriatric compared to pediatric cases after 100 months binarizing patients according to median case volume (HR 1.280; CI: 1.017–1.611; p = 0.03) 1. 5-year DSS was 81.0% (West), 79.8% (East), 67.4% (Midwest), and 72.7% (South); p = 0.018 2. 10-year DSS was 74.0% (West), 73.7% (East), 60.9% (Midwest), and 63.6% (South); p = 0.017 Isocitrate dehydrogenase 2 (IDH2) mutation-positive tumors had more aggressive behavior and conferred a poor prognosis 1. The 5-year OS and DFS rates were 89.1% and 79.2%, respectively 2. The overall surgical complication incidence was 9.52% (one cerebrospinal fluid rhinorrhea, one cervical hematoma, and two epileptic seizures) 5-year OS and event-free survival were44.4% Worse prognosis was seen at low-facility centers when

2018 3

Retrospective cohort

N = 35 ONB without skull base involvement

Sharma et al. 84

2022 4

Retrospective database study (SEER) Retrospective database study (NCDB)

N = 561 patients with ONB

1. DSS 2. OS

Barinsky et al. 85

N = 533 patients with ONB

OS

2021

4

Berger et al. 6

2021

4

Retrospective database study (NCDB) Retrospective database study (SEER) Retrospective database study (NCDB) Retrospective database study (SEER)

N = 1411 patients with ONB

IS

Burnhan et al. 86

N = 882 patients with ONB

1. DSS 2. OS

2021

4

Goshtasbi et al. 87

2021

4

N = 1601 patients with ONB

OS

Mikhael et al. 88

N = 987 patients with ONB

1. DS

2021

4

Wuet al. 89

2022 4

Retrospective case series

N = 82 patients with ONB

OS

Cai et al. 90

2021

4

Retrospective case series

N = 42 patients with ONB

1. OS 2. DFS

Dumont et al. 91

2020 4

Retrospective case series

N = 18 Pediatric ONB

OS

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