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KUANetal.

TABLE XXIV.B.1 Evidence surrounding multimodal treatment of sinonasal undifferentiated carcinoma.

Clinical endpoints

Study

Year LOE Study design Study groups

Conclusion

Faisal et al. 1412

OS

80% lower risk of regional failure withENT

255 patients from 12 studies: ENT (126), no ENT (129)

2020 2

Systematic

reviewand meta analysis reviewand meta analysis

Morand

2017 2

Systematic

390 total from 29

OS

Bi- or trimodal treatment is superior to single modality

et al. 1394

studies: Treatment known: Sx + CRT (61), CRT (49), Sx + RT(37), RT (24), palliative (16), Sx (14) 167 patients from 30 studies: C (6), RT (21), CRT (36), Sx (15), Sx + C(1), Sx + RT(46), Sx + CRT (34), no Tx (8) IC (all patients): CRT (60), CRT + Sx (31), Sx + RT(4) Sx (37), Sx + RT(32), Sx + CRT(157), Sx + C (14), RT (16), CRT (120), C (25), no Rx (34) Sx (15), RT (43), C (7), Sx + RT(54), Sx + C (2), Sx + CRT(110), CRT (85), palliative (31) Induction RT + Sx (23), Sx + RT(61) CRT (16), Sx + CRT (11), Sx + RT(4) Sx + RT (142), RT (111) Sx (33); C not defined IC + Sx + RT(15), IC + Sx (3), IC + RT (52) CRT(8), IC + CRT(8), palliative (3), Sx + CRT(2) Sx + CRT (22), CRT (4), Sx (1) No IC (370), (70),

OS

Trend for better OS with surgery with RT or CRT

Reiersen

2012 2

Systematic

et al. 1441

reviewand meta analysis

Amit et al. 1403

2019 3

Retrospective cohort

OS

OS benefit for IC guide for CRT or surgery with RT/CRT

Kuoet al. 1402

OS

OS benefit from CRT or surgery withCRT

2017 3

Retrospective cohort

van der Laan et al. 1404

2016 3

Systematic

DFS

Better DFS for surgery with RT than CRT

reviewand meta analysis

Fuet al. 1416

Neoadjuvant RT associated with negative margins

2016 3

Retrospective cohort

1. Margin control 2. OS 3. DFS 4. LRFS 5. RFS

Chamberlain et al. 1442

2016 3

Retrospective cohort Retrospective cohort Retrospective Database Study (NCDB) Retrospective case series

OS

CNS involvement associated with poorer outcomes

OS

Better OS with surgery and adjuvant RT

Chambers et al. 1405

2015 3

Lehrich et al. 1415 2020 4

OS

IC not associated with improved OS

London et al. 1414 2020 4

OS

Nonstatistically analyzed trend supporting IC

Workman et al. 1395

2019 4

Retrospective case series

OS

Nodal disease at presentation associated with worse OS

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