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ICAR SINONASAL TUMORS
TABLE XXIV.B.1 (Continued)
Clinical endpoints
Study
Year LOE Study design Study groups
Conclusion
1. OS 2. DFS
IC associated with improved DFS
de Bonnecaze et al. 497
2018 4
Retrospective case series
CRT (29), Sx + CRT (14), Sx + RT(6), other (5) Sx + CRT (16), Sx + RT, IC + Sx + CRT(8), RT (4), CRT (3) Sx + CRT (169), CRT (146) Sx + RT(3), Sx + CRT (4), RT (6), CRT (4), PRT(4)
Gamez et al. 499
2017 4
Retrospective case series
OS
Trimodal treatment with > 60Gy superior to bimodal
Khanet al. 367
OS
Better OS for surgery with surgery than CRT when resectable
2017 4
Retrospective Database (NCDB) Retrospective case series Retrospective Database Study (SEER) Retrospective Database Study (SEER) Retrospective case series Retrospective case series Retrospective case series Retrospective case series Retrospective case series Retrospective case series Retrospective case series Retrospective case series
Bhasker
2017 4
OS
Supports surgery with adjuvant treatment
et al. 1443
Kuanet al. 1407
1. OS 2. DFS
Kadish stage, age, and radiation associated with OS, DFS
Sx + RT (150), RT
2016 4
(108), Sx (32), none (22), unknown (16)
Ahnet al. 229
2016 3
No neck dissection (104), neck dissection (7)
Metastasis
Nonnasal, non-ethmoid tumors associated with metastasis
Lopez et al. 1397
OS
Supports surgery with adjuvant RT
2015 4
Sx + CRT (10), Sx + RT (1), C + Sx + CRT (3), CRT (3) Sx + CXT (8) CRT (3) Sx + CRT (7), CRT (7), RT(1) Sx + CRT (10), Sx + RT (5), CRT (6), RT (2) Sx + CRT(4), Sx + RT (4), RT(4) CRT(7), C + Sx + RT (7), Sx + RT(5), Sx + CRT(2) Sx + CRT (6), Sx with RT (5), CRT (1), Sx (1), IC + Sx + RT(1) No Rx (2, 5), single modality (7, 42), CRT (4, 37), Sx + RT (3, 22), Sx + CRT(4, 34) Sx (3), Sx + CRT(5), CRT + Sx (7), CRT (3) CRT(4), Sx + CRT(4), Sx + RT (3), RT (3) CRT (6), Sx (6), Sx + CRT(4)
Grayet al. 1444
2015 4
OS
Improved OS with HPV-associated SNUC Trend toward OS benefit with CRT Supports surgery with adjuvant CRT Endoscopic surgery comparable to open Recommend three- or two-modality treatment
Liaoet al. 1445
2014 4
OS
Christopherson et al. 1446
2014 4
OS
Suet al. 1447
2014 4
OS
Al-Mamgani et al. 1413
2013 4
OS
Yoshida
2013 4
OS
Trend supporting surgery with CRT
et al. 1448
Millard et al. 1449
2013 4
OS
Support primary CRT followed by surgery, ENT
Xuet al. 1450
OS
Multimodal treatment associated with better OS
2013 4
Retrospective case series
Mourad et al. 1451 2013 4
Retrospective case series
1. OS 2. DFS
Trimodal therapy associated with betterDFS
Lee et al. 1452
2012 4
Retrospective case series
OS
Supports surgical resection with CRT
(Continues)
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