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ICAR SINONASAL TUMORS

TABLE XXIV.B.1 (Continued)

Clinical endpoints

Study

Year LOE Study design Study groups

Conclusion

1. OS 2. DFS

IC associated with improved DFS

de Bonnecaze et al. 497

2018 4

Retrospective case series

CRT (29), Sx + CRT (14), Sx + RT(6), other (5) Sx + CRT (16), Sx + RT, IC + Sx + CRT(8), RT (4), CRT (3) Sx + CRT (169), CRT (146) Sx + RT(3), Sx + CRT (4), RT (6), CRT (4), PRT(4)

Gamez et al. 499

2017 4

Retrospective case series

OS

Trimodal treatment with > 60Gy superior to bimodal

Khanet al. 367

OS

Better OS for surgery with surgery than CRT when resectable

2017 4

Retrospective Database (NCDB) Retrospective case series Retrospective Database Study (SEER) Retrospective Database Study (SEER) Retrospective case series Retrospective case series Retrospective case series Retrospective case series Retrospective case series Retrospective case series Retrospective case series Retrospective case series

Bhasker

2017 4

OS

Supports surgery with adjuvant treatment

et al. 1443

Kuanet al. 1407

1. OS 2. DFS

Kadish stage, age, and radiation associated with OS, DFS

Sx + RT (150), RT

2016 4

(108), Sx (32), none (22), unknown (16)

Ahnet al. 229

2016 3

No neck dissection (104), neck dissection (7)

Metastasis

Nonnasal, non-ethmoid tumors associated with metastasis

Lopez et al. 1397

OS

Supports surgery with adjuvant RT

2015 4

Sx + CRT (10), Sx + RT (1), C + Sx + CRT (3), CRT (3) Sx + CXT (8) CRT (3) Sx + CRT (7), CRT (7), RT(1) Sx + CRT (10), Sx + RT (5), CRT (6), RT (2) Sx + CRT(4), Sx + RT (4), RT(4) CRT(7), C + Sx + RT (7), Sx + RT(5), Sx + CRT(2) Sx + CRT (6), Sx with RT (5), CRT (1), Sx (1), IC + Sx + RT(1) No Rx (2, 5), single modality (7, 42), CRT (4, 37), Sx + RT (3, 22), Sx + CRT(4, 34) Sx (3), Sx + CRT(5), CRT + Sx (7), CRT (3) CRT(4), Sx + CRT(4), Sx + RT (3), RT (3) CRT (6), Sx (6), Sx + CRT(4)

Grayet al. 1444

2015 4

OS

Improved OS with HPV-associated SNUC Trend toward OS benefit with CRT Supports surgery with adjuvant CRT Endoscopic surgery comparable to open Recommend three- or two-modality treatment

Liaoet al. 1445

2014 4

OS

Christopherson et al. 1446

2014 4

OS

Suet al. 1447

2014 4

OS

Al-Mamgani et al. 1413

2013 4

OS

Yoshida

2013 4

OS

Trend supporting surgery with CRT

et al. 1448

Millard et al. 1449

2013 4

OS

Support primary CRT followed by surgery, ENT

Xuet al. 1450

OS

Multimodal treatment associated with better OS

2013 4

Retrospective case series

Mourad et al. 1451 2013 4

Retrospective case series

1. OS 2. DFS

Trimodal therapy associated with betterDFS

Lee et al. 1452

2012 4

Retrospective case series

OS

Supports surgical resection with CRT

(Continues)

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