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307

ICAR SINONASAL TUMORS

TABLE XXVI.1 (Continued) Study

Year LOE Study design Study groups

Clinical endpoints Conclusion

B-cell primary lymphoma of the maxillary sinus has a good prognosis in contrast to T-cell lymphomas that originate from midline structures

1. Site of primary tumor 2. OS

Nakamura et al. 1806

1997 3

Retrospective cohort

CT data and clinical outcomes of 24

patients with Stage 1 and2 non-Hodgkin’s lymphoma

Eide et al. 1792

2022 4

Retrospective case series

85 sinonasal

1. Signs and symptoms 2. DSS

Facial swelling was most common presenting symptom

lymphoma patients

Lei et al. 1793

Treatment outcomes 1. 5-year OS was 73.4%, PFS was 51.1% 2. Length of CRS symptoms correlated with stage at diagnosis (not true for non-UAT ENKTL) 3. Patients without CRS had a significantly better PFS 4. CRS did not affect response to treatment

2022 4

Retrospective case series

214 ENKTL patients treated at a single institution

Desai et al. 1813

2021 4

Retrospective case series

25 cases of primary sinonasal tract DLBCL 59 ENKTL and 27 DLBCL patients treated at a single institution

Histopathological analysis

DLBCL primary to the sinonasal tract is histopathologically heterogeneous 1. ENKTL tended to be located in the nasal cavity, heterogeneous intensity, internal necrosis, and solid component 2. DLBCL located more often in sinus, homogenous, mild enhancement, septal enhancement, and with intracranial/orbital involvement ENKTLs localized in the nasal cavity with poor to moderate enhancement, DLBCLs were located in the paranasal sinuses with intense enhancement 1. OS was significantly different among three distinct DLBCL patient groups 2. Primary DLBCL of the sinonasal tract is a distinct disease entity ofDLBCL 1. Patients rarely have B symptoms (only 13%) 2. Presentation is nonspecific making diagnosis challenging 3. Biopsies should be performed when suspecting sinonasal lymphoma (Continues)

Chenet al. 1803

Imaging Findings

2020 4

Retrospective case series

He et al. 1804

2019 4

Retrospective case series

60 patients with ENKTL and 26 patients with

Imaging findings

DLBCL treated at a single institution with MRI scans

Murakami et al. 1815

1. OS 2. Lymphoma

2019 4

Retrospective case series

Clinicopathological analysis of 151

subtype analysis

sinonasal malignant lymphoma patients in an HTLV-1

endemic area in Fukuoka, Japan

Storck et al. 1795

2019 4

Retrospective case series

221 patients with head and neck lymphoma treated at a single

Presenting

symptoms

institution, (193 NHL, 28 HL, one ENKTL)