xRead - Nasal Obstruction (September 2024) Full Articles

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KUANetal.

TABLE XXVI.1 (Continued) Study

Year LOE Study design Study groups

Clinical endpoints Conclusion

Varelas et al. 1835 2019 4

1. Most common primary sites of DLBCL were maxillary sinus (36.1%) and nasal cavity (34.5%) 2. Nasal cavity more common among Asian/Pacific Islands (43.4%) 3. Maxillary sinus more common for Caucasians (36.3%) and African Americans (42.1%) 4. OS was 70% at 2 years, 54% at 5 years, and 38% at 10 years 1. Angiocentric/destructive pathology 2. Tumor cells expressed several markers (CD3, CD43, CD56, TIA-1, granzyme B, perforin) andEBV + 3. CXRT was given but treatment outcomes were poor 1. Sinonasal symptoms are the most common presenting symptoms 2. Bhutan may be endemic for EBV/ENKTL 3. Necrosis and angiocentricity are common 4. Chemotherapy (SMILE/CHOP) and radiotherapy were used based on stage of disease characteristic genomic profile 2. High RGS1 IHC expression is associated with poor OS Biopsies with small lymphocytic infiltrates, chronic inflammation, surface ulceration, and 1. 84% were primary lesions 2. Presenting symptoms were primarily nonspecific nasal complaints 3. Nasopharynx followed by nasal cavity was the most common subsite Note that diagnosis remains challenging due to nonspecific presentation Presenting symptoms are not specific, multiple biopsies may be necessary (Continues) 1. Sinonasal DLBCL has a microscopic bone invasion should alert pathologist to ENKTL

1273 cases of DLBCL of the sinonasal tract

1. Prognostic

Retrospective database study (SEER)

disease- specific survival

2. OS

Zhiyan et al. 1830 2018 4

Retrospective case series

17 patients treated for ENKTL at a single institution

1. Presenting symptoms 2. Treatment outcomes

Arora et al. 1787

2017 4

Retrospective case series

Nine patients treated in India over 2 years

1. Presenting symptoms 2. Treatment outcomes

Carreras

2017 4

Retrospective case series

Clinicopathological

Microarray DNA hybridization of DLBCL

et al. 1814

characteristics of 29 primary sinonasal DLBCL ENKTL treated at multiple institutions (10 patients with sinonasal disease)

McKelvie et al. 1817

Histopathology

2016 4

Retrospective case series

13 patients with

Vahamurto et al. 1797

2016 4

Retrospective case series

142 patients treated

Presenting

over almost 40 years at single institution (five ENKTL)

symptoms

Tusaliu et al. 1782 2015 4

Retrospective case series

Patients treated at a single institution

Presenting

symptoms

Miyake et al. 1790 2014 4

Retrospective case series

Seven patients treated at a single institute

Presenting

symptoms