xRead - Nasal Obstruction (September 2024) Full Articles

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309

ICAR SINONASAL TUMORS

TABLE XXVI.1 (Continued) Study

Year LOE Study design Study groups

Clinical endpoints Conclusion

1. All three patients passed away despite CXRT 2. All three ultimately had extraocular muscle involvement and presented with painless eyelid swelling 1. Non-GCB subtype was previously thought to show poor prognosis 2. Prognosis for localized nasal/paranasal DLBCL patients was good irrespective of subclassification 1. Elevated beta-2 microglobulin was defined as > 2.5mg/L 2. Patients with high B2M at diagnosis had worse 5-year OS (35.2% vs. 73.6%) and worse PFS (27.5% vs. 55.9%) 1. Nine patients died and only four remain in remission at follow-up 46months 2. Addition of chemotherapy did not improve outcomes in advanced stage 1. As many as 37.5% of patients were referred for rhinitis and/or sinusitis 2. Many patients required multiple biopsies for definitive diagnosis 1. All patients had false-negative biopsies, leading to treatment delay 2. 50%OS 1. Inhomogeneous contrast agent enhancement as well as bony erosion of the sphenoid sinus were identified on CT and MRI 2. Cross-sectional imaging is not sufficient to establish the diagnosis of a primary NHL in the sphenoid sinus 1. Nasal biopsies showed CD3 + andCD56 + cells 2. Tumor cells were detected in marrow and peripheral blood 3. All patients died within 48 months of diagnosis despite treatment

1. Presenting symptoms 2. Treatment outcomes

Termote

2014 4

Retrospective case series

Three patients treated at a single center withENKTL involving the orbit

et al. 1801

Todaet al. 1816

2013 4

Retrospective case series

Clinicopathologic

Comparison

review of 39 patients with localized nasal/paranasal DLBCL

between DLBCL subtypes with nongerminal center B-cell-like (non-GCB) and germinal center B-cell-like (GCB)

Li et al. 1831

Survival

2012 4

Retrospective case series

82 patients with

ENKTL treated at a single center

Tababi et al. 1886

2012 4

Retrospective case series

15 patients with

1. Survival 2. Treatment response

ENKTL treated at a single institution

Yenet al. 1791

Presenting

2012 4

Retrospective case series

33 patients treated for SN lymphoma at a single institution

symptoms

Sands et al. 1785

2008 4

Retrospective case series

Four patients treated at a single institution

1. Presenting symptoms 2. Survival

Bisdas et al. 1805

1. Morphological CTandMR imaging 2. Perfusion CT imaging and protonMR spectroscopy

2007 4

Retrospective case series

Three patients with

primary BCL of the sphenoid sinus

Falcao et al. 1826

2007 4

Retrospective case series

Three patients treated at a single institution who underwent immunophenotyp ing via flow

Histopathology

cytometry in the leukemic phase

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