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310

KUANetal.

TABLE XXVI.1 (Continued) Study

Year LOE Study design Study groups

Clinical endpoints Conclusion

Ouet al. 1800

2007 4

Retrospective case series

24 patients with biopsy proven ENKTL

Imaging findings

1. CT and MRI findings are nonspecific 2. Bony erosion and local invasion are common 1. 49 patients had ENKTL 2. Higher mortality rates were noted in chemotherapy alone group, but combination CRT failed to show significantly better survival (5-year OS was 35.1%) Demonstration of mixed lineage (NK and T cell) via histopathology 1. ENKTL was more common than BCL 2. No racial association with ENKTL 3. ENKTL shows an aggressive 1. Two clinical groups: one at the terminal stage of disease, the other at time of presentation 2. Poor prognosis thought to be due to resistance to chemotherapy 1. Lesions were consistent with either ENKTL or Granulomatosis with Polyangiitis (GPA) 2. ENKTL was positive for CD 20, 45, and 45RO 3. There were no imaging findings found to differentiate NK/T cell andGPA Despite being less common, histology of North American lymphoma is similar to Asian samples 1. Presence of bone erosion is suggestive of the disease but not diagnostic 2. Involvement of hard palate, orbit, and nasopharynx was found in 50% of cases 1. Poor prognosis with median survival of 6 months 2. EBER detected in 16 out of 18 patients phenotype similar to Asian studies with EBV association

Wooet al. 1784

2004 4

Retrospective case series

50 patients with

OS

extranodal NHL

Linet al. 1887

1. Survival 2. Histopathology

2003 4

Retrospective case series

15 patients treated for ENKTL at a single institution

Altemani et al. 1888

2002 4

Retrospective case series

25 patients with

1. Presenting symptoms 2. Patient survival

midface lymphoma treated in Brazil

Takahash et al. 1889

Survival

2001 4

Retrospective case series

20 patients with ENKTLand

hemophagocytic syndrome

Borges et al. 1807

2000 4

Retrospective case series

Nine patients with

1. Histopathology 2. Imaging findings

midline granuloma

Gaal et al. 1789

Histopathology

2000 4

Retrospective case series

15 patients with

ENKTL treated at a single North American institute; 12 had sinonasal lesions radiologic imaging and biopsy proven ENKTL

Ooi et al. 1799

2000 4

Retrospective case series

Nine patients with

Imaging findings

Harabuchi et al. 1822

1. OS 2. Histopathologic features

1998 4

Retrospective case series

18 patients with

ENKTL treated at a single institution

(Continues)