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311

ICAR SINONASAL TUMORS

TABLE XXVI.1 (Continued) Study

Year LOE Study design Study groups

Clinical endpoints Conclusion

Kohshima et al. 1828

1997 4

Retrospective case series

Eight patients with ENKTL

Histopathology

1. Two cases were CD3 + CD56 + and six were CD3-CD56 + , all showedEBV + 2. FasL and perforin were expressed, suggesting both paths are used in tumor cytotoxicity 1. 88% showed null or T-cell phenotype and EBV in situ hybridization 2. The frequency and presentation in Guatemala were similar to Asian and Peruvian series 5-year OS was 63% with mean survival time of 84.2 months 1. EBERISH + was found in all ENKTL 2. EBER ISH was strongly suggestive of absence of ENKTL EBV is strongly associated with sinonasal localization and expression of ENKTL antigens XRT with or without chemotherapy performed better than chemotherapy alone 1. EBER + in 12 SN lymphomas with T-cell phenotype 2. EBER + and ENKTL were found tobe angiodestructive/angiocentric Eight of the cases had TCR-CD56 + markers, suggesting NK cell lineage 1. In 13 of the patients (11 ENKTL) EBV RNA was detected 2. CD43 + was found in EBV-infected cells 3. Similar to cohorts from Asia 1. Angioinvasive lesions had worse prognosis 2. Combined therapy should be considered for angioinvasive lymphoma (Continues)

VandeRijn et al. 1788

1997 4

Retrospective case series

33 cases of ENKTL treated in Guatemala

Presenting

symptoms

Yanget al. 1890

1. Clinicopathologic data 2. OS

1997 4

Retrospective case series

34 patients with sinonasal lymphomas at

Taichung Veterans General Hospital 12 cases of NK/T-cell lymphoma, 23 cases of rhinitis, 10 cases ofGPA 55 patients with upper aerodigestive non-Hodgkin’s lymphoma; 27 had sinonasal lymphoma; 23 were ENKTL

Dictor et al. 1821

1996 4

Retrospective case series

Histopathology

Histopathology

Kanavaros et al. 1891

1996 4

Retrospective case series

Gorpet al. 1892

1995 4

Retrospective case series

13 patients with

1. OS 2. Treatment response Histopathology

ENKTL treated at a single center

Lee et al. 1818

1994 4

Retrospective case series

13 sinonasal and 18 Waldeyer’s ring

lymphomas treated at a single center

Suzumiya et al. 1829

1994 4

Retrospective case series

Nine patients with

Histopathology

non-Hodgkin’s SN lymphoma

Arber et al. 1820

Histopathology

1993 4

Retrospective case series

14 patients with sinonasal

lymphoma treated inPeru

Aviles et al. 1819

1992 4

Retrospective case series

65 patients with

1. Histopathology 2. treatment response

sinonasal or hard palate lymphoma