xRead - Nasal Obstruction (September 2024) Full Articles

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KUANetal.

TABLE XXXII.2 Evidence surrounding QOL after surgical treatment for SNM.

Clinical endpoints

Study

Year LOE Study design Study groups

Conclusion

1. SNOT-22 scores initially decreased after surgery at < 4weeks but subsequently improved to better than baseline by 12 weeks 2. Intranasal pathology was associated with worse preoperative SNOT-22 scores than intracranial pathology alone, and this difference persisted at 52 weeks 1. 16% of patients had a complication, including CSF leak, visual changes, meningitis, and CRS 2. Adjuvant RT was not associated with odds of complications 3. Male sex was associated with decreased odds of complication and open resection was associated with increased odds of complication 1. SNOT-22 scores were higher in patients with malignant disease at baseline 2. There was an improvement in SNOT-22 scores from baseline to 2 years in patients with malignant tumors 3. Much of the improvement in sinonasal QOL was seen in rhinologic and sleep subdomains 4. Decreased SNOT-22 scores were seen in those who received adjuvant RT or chemotherapy 1. Patients undergoing NSF reconstruction had deterioration of olfaction from baseline to 6 weeks, but this improved to baseline by 3 months postoperatively 2. Patients without NSF had no difference between baseline and 6-week postoperative olfaction, and had improvement by 3 months 1. In the SNM group, overall and rhinologic subdomain SNOT-20 scores did not improve over 2 years, while they did improve in the IP group 2. Improvement in psychologic and sleep subdomains was seen at 1 and 2years 3. History of smoking was associated with higher overall scores (Continues)

SNOT-22 scores preoperatively and postopera tively up to 96weeks

1025 patients

Bhenswala et al. 2125

2019 2

Meta-analysis of prospective

undergoing EEA for skull base pathologies, including 137 with SNM

cohort studies

Beswick et al. 14

2021 3

Prospective cohort

1. 44 patients undergoing

Surgical

complications

resection of SNM viaan open/combined approach

2. 98 patients undergoing

resection of SNM viaEEA

Glicksman et al. 2093

SNOT-22 scores preoperatively andover a 2-year follow-up period

2018 3

Prospective cohort

145 patients with

malignant ( n = 64) or benign ( n = 81) sinonasal tumors undergoing endoscopic tumor resection

Upadhyay et al. 2132

2017 3

Prospective cohort

42 patients undergoing endoscopic resection of skull base tumors

Olfaction as

measured by the UPSIT at baseline and various points postopera tively

withNSF ( n = 7) and without NSF ( n = 35)

Derousseau et al. 2090

SNOT-20 scores over 2 years after surgery

2015 3

Prospective cohort

1. 72 patients with SNM undergoing EEA 2. 32 patients with IP (control)