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259

Orlandi et al.

(Continues)

Asthma was significantly more frequent in CRS patients.

associated with adult-onset asthma or late-onset asthma (onset after 40 years), whereas CRS

without nasal polyps was

related to childhood-onset asthma or early-onset

asthma (onset before 40 years).

The association of comorbid asthma with lower QoL in CRS is related to the

clinical status (eg, control) of asthma.

The prevalence of asthma was 9.95, 21.16, 46.9, and 73.3%

in the 4 groups respectively.

Study Year LOE Study Design Study Groups Clinical Endpoint Conclusions

CRSwNP was significantly

Impact of CRS on HRQoL, comorbidity incidence,

objective disease measures, and medical and surgical

treatments were collected

To investigate relationships between CRSwNP and asthma characteristics

associated with lower QoL inCRS

Identify the prevalence of asthma

Determine if asthma is

Won 197 2018 3 Cross-sectional study A cross-sectional data set of 17,506 adult participants ( ≥ 18 years old) in the

237 CRSsNP; 445 CRSwNP; 187 controls

Korean National Health

and Nutrition Examination Survey

were recruited (28.3% were asthmatic)

participants: 221 controls,

553 CRSsNP, 651 CRSwNP and 45 allergic fungal rhinosinusitis (AFRS)

350 participants with CRS

Included 1470 study

cross-sectional

case-control study

Campbell 190 2018 3 Cross-sectional cohort study

Philpott 196 2018 3 Prospective case-control multicenter study

Khan 195 2018 3 Multicenter

TABLE V-4 (Continued)