xRead - Nasal Obstruction (September 2024) Full Articles

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International consensus statement on rhinosinusitis

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TABLE VII-7 Evidence for viruses as a contributing factor for ARS Study Year LOE Study Design Study Groups Clinical Endpoint Conclusions Koch 370 2018 3 Prospective viral challenge Healthy adults; RV challenge RV infection; cytokine induction RV challenge increases inflammatory cytokines but lowers cytokine response to subsequent RV infection Hofstra 368 2015 3 Prospective viral challenge Healthy adults; RV challenge Patient symptoms scores; bacterial load Non-significant trends toward increased load of pathogenic bacteria following challenge Jackson 375 2015 3 Prospective viral challenge

Allen 369 2014 3 Prospective viral challenge Bacterial profiles did not change with RV inoculation DeMuri 376 2019 4 Case-control Longitudinal Healthy adults; RV challenge Bacterial load and species; symptom scores

Total 55% viral detection in ARS (day 10 symptoms); RSV at day 3 associated

with ARS; 1/3 had different virus at day 3 & day 10

RV increased nasal IL-18, with attenuated response in asthmatic patients

follow-up, child served as own control Essentially unchanged from interim data below DeMuri 377 2018 4 Case-control Longitudinal Viral detection; bacterial culture

Viral detection; bacterial culture

Symptoms, nasal IL-18 levels

follow-up, child served as own control

Healthy and asthmatic adults; RV challenge