xRead - Nasal Obstruction (September 2024) Full Articles

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289

Orlandi et al.

(Continues)

Nino 381 2014 4 Case-control Children hospitalized for acute respiratory illness TSLP, CCL11/eotaxin1 Increased airway secretion of TSLP and CCL11/eotaxin-1 with RV infection

Increased systemic and local inflammation in ABRS,

influenza, adenovirus, or multi-viral infection

Kloepfer 380 2017 4 Cohort study RV associated with increases in pathogenic bacteria DeMuri 366 2016 4 Case-control Longitudinal follow-up, child served as own control Clinically diagnosed sinusitis 8.8% of URI developed (uncontrolled) Asthmatic children followed prospectively RV infection, bacterial cultures of nasal secretions

production could predict viral infection

immune response (IL-6

pathway) in control and asthmatics; differential

IL-10 expression between groups

sinusitis; RV most common virus

Study Year LOE Study Design Study Groups Clinical Endpoint Conclusions

Alterations in cytokine

Upregulation of early

Autio 379 2017 4 Cohort study Adults; clinical ARS Inflammatory markers; viral PCR or positive bacterial culture

Landry 378 2018 4 Cases-series Adults with acute URI Viral detection, cytokine production

expression, symptom diary

Nasal epithelial gene

Heymann 371 2017 4 Case-control Adult asthmatics and healthy controls

TABLE VII-7 (Continued)