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304

International consensus statement on rhinosinusitis

antihistamine use in ABRS based on

Grade D evidence, first principles

Peters 451 2014 5 Guideline No evidence for use of antihistamines in

ARS (option, Grade D)

use of antihistamines in ABRS (strong

recommendation, low-moderate evidence)

TABLE VII-15 Evidence for antihistamines in ARS treatment Study Year LOE Study Design Study Groups Clinical Endpoint Conclusions Braun 356 1997 3 DBRCT Patient with ARS (ages 15-65) and comorbid AR treated with amoxicillin/clavulanic acid, prednisone and: – Loratadine –Placebo Symptom score cards Clinical exam including rhinoscopy Significant improvement in total symptom scores Rosenfeld 88 2015 5 Guideline Discourage

Fokkens 26 2020 5 Guideline No recommendation.

Chow 32 2012 5 Guideline Recommend against