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Orlandi et al.

(Continues)

RUNX2, transcription factor in osteoblast proliferation and differentiation.

TABLE IX-6 Evidence for neo-osteogenesis as a contributing factor for CRS Study Year LOE Study Design Study Groups Clinical Endpoint Conclusions Snidvongs 646 2019 2 Systematic review CRS patients Pathogenesis of neo-osteogenesis in CRS remains unknown. Leung 645 2016 2 Systematic review CRS patients HU correlate with Histopathological grade of osteitis. Sethi 644 2015 2 Systematic review CRS patients Previous surgery correlates with higher overall GOSS. Bhandarkar 265 2013 2 Systematic review CRS patients Neo-osteogenesis may impact improvement following treatment.

Videler 643 2011 2 Systematic review CRS patients No evidence of active bacterial infection in the bone.

antibiotics or radical surgery.

Chiu 642 2005 2 Systematic review CRS patients Neo-osteogenesis may impact disease management. Khalmuratova 670 2019 3 Prospective case control CRS patients (n = 67), Control (n = 11) Protein expression IL-13 and IL-17A induce

Levels of RANKL correlate with osteitis scores and disease severity.

Georgalas 653 2013 2 Systematic review CRS patients No evidence for long-term

Histopathology, GOSS, Protein expression

CRSsNP (n = 8),

CRSwNP (n = 63),

Control (n-12)

undergoing ESS

Kong 673 2019 3 Prospective case control