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340

International consensus statement on rhinosinusitis

(Continues)

Increased TGF- β 1 expression

in ethmoid bone of CRSwNP compared to controls and CRSsNP.

CRSsNPand neo-osteogenesis (n = 8), Control patients (n = 8) Gene expression profiling GDF5 upregulated in osteitic bone. CRSwNP (n = 20), CRSsNP (n = 20), control (n = 20)

Decreased osteoblast adhesion and increase calcium content in CRS.

common in CRS. Correlation between previous surgery and neo-osteogenesis.

BMP signaling dysregulation correlates with degree of osteitis.

Osteitis histopath grade higher with increasing biofilm volume and score.

CT bone density (HU) HU different between controls and CRS patients. GOSS, histopathology, protein expression

No difference in bacterial colonization of bone

between CRS patients and controls.

Study Year LOE Study Design Study Groups Clinical Endpoint Conclusions Wu 672 2019 3 Prospective case control CRS patients with neo-osteo (n = 10), control (n = 10)

Neo-osteogenesis more

GOSS, osteoblast phenotype and

proliferation, bone mineralization

Global Osteitis Scoring Scale, Lund-Mackay grading scale

Protein expression, GOSS, KOS

Histopathology, biofilm volume and score, GOSS, CT(HU)

Presence of bacterial colonies in bone samples

CRSsNP (n = 16),

CRS patients undergoing surgery (n = 9), controls (n = 5) CRSwNP (n = 8), CRSsNP (n = 8), control (n = 6)

controls (n = 68)

CRS patients undergoing surgery (n = 84), control (n = 22)

control (n = 10)

CRSwNP (n = 23),

CRS (n = 102) and

undergoing sinus CT

Gunel 671 2017 3 Prospective case control

Wang 667 2015 3 Prospective case control

Stevens 669 2014 3 Prospective case control

Georgalas 657 2010 3 Prospective case control

Emre 654 2015 3 Prospective case control

Dong 664 2014 3 Prospective case control

Wood 652 2012 3 Prospective case control

TABLE IX-6 (Continued)