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341

Orlandi et al.

(Continues)

Poor response to treatment in SPECT positive patients.

Bone remodeling increased in CRS group compared to controls.

Pseudomonas isolated more frequently in CRS with neo-osteogenesis.

Snidvongs 650 2014 4 Prospective case series CRS patients undergoing primary ESS (n = 22) Histopathology Neo-osteogenesis present, no bone inflammation.

with worse mucosal disease and revision surgery.

Neo-osteogenesis predicted higher recurrence. Saylam 656 2009 3 Prospective cohort CRS patients with and without neo-osteogenesis SPECT scores, subjective response to treatment Giacchi 649 2001 3 Prospective case control

resorption identified in CRS.

neo-osteogenesis between primary and revision surgery.

GOSS and KOS correlated with P-gp expression.

CRS patients undergoing ESS (n = 20), control (n = 5) Histopathology Neo-osteogenesis and bone CRS patients (n = 24)& controls (n = 9)

Study Year LOE Study Design Study Groups Clinical Endpoint Conclusions Telmesani 641 2010 3 Prospective case control CRSwNP patients

Neo-osteogenesis associated

Gunel 637 2015 4 Prospective case series CRS patients undergoing primary (n = 74) and revision (n = 37)ESS Histopathology No difference in

Histology of bone and mucosa

SNOT22, LM score, GOSS, Bacterial profile

Histopathology. Disease recurrence

Gunel 668 2014 4 Prospective case series CRS patients (n = 38) Histopathology, GOSS, KOS, P-glycoprotein expression

CRS patients undergoing ESSwith (n = 30) and without (n = 60) neo-osteogenesis

undergoing primary (n = 50) and revision (n = 32)ESS

undergoing ESS

Kennedy 638 1998 3 Prospective case control

Huang 662 2015 4 Retrospective case series

TABLE IX-6 (Continued)

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