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Orlandi et al.
(Continues)
Poor response to treatment in SPECT positive patients.
Bone remodeling increased in CRS group compared to controls.
Pseudomonas isolated more frequently in CRS with neo-osteogenesis.
Snidvongs 650 2014 4 Prospective case series CRS patients undergoing primary ESS (n = 22) Histopathology Neo-osteogenesis present, no bone inflammation.
with worse mucosal disease and revision surgery.
Neo-osteogenesis predicted higher recurrence. Saylam 656 2009 3 Prospective cohort CRS patients with and without neo-osteogenesis SPECT scores, subjective response to treatment Giacchi 649 2001 3 Prospective case control
resorption identified in CRS.
neo-osteogenesis between primary and revision surgery.
GOSS and KOS correlated with P-gp expression.
CRS patients undergoing ESS (n = 20), control (n = 5) Histopathology Neo-osteogenesis and bone CRS patients (n = 24)& controls (n = 9)
Study Year LOE Study Design Study Groups Clinical Endpoint Conclusions Telmesani 641 2010 3 Prospective case control CRSwNP patients
Neo-osteogenesis associated
Gunel 637 2015 4 Prospective case series CRS patients undergoing primary (n = 74) and revision (n = 37)ESS Histopathology No difference in
Histology of bone and mucosa
SNOT22, LM score, GOSS, Bacterial profile
Histopathology. Disease recurrence
Gunel 668 2014 4 Prospective case series CRS patients (n = 38) Histopathology, GOSS, KOS, P-glycoprotein expression
CRS patients undergoing ESSwith (n = 30) and without (n = 60) neo-osteogenesis
undergoing primary (n = 50) and revision (n = 32)ESS
undergoing ESS
Kennedy 638 1998 3 Prospective case control
Huang 662 2015 4 Retrospective case series
TABLE IX-6 (Continued)
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