xRead - Nasal Obstruction (September 2024) Full Articles

20426984, 2021, 3, Downloaded from https://onlinelibrary.wiley.com/doi/10.1002/alr.22741 by Stanford University, Wiley Online Library on [01/07/2024]. See the Terms and Conditions (https://onlinelibrary.wiley.com/terms-and-conditions) on Wiley Online Library for rules of use; OA articles are governed by the applicable Creative Commons License

345

Orlandi et al.

(Continues)

82% of CRS patients had abnormal pH test at

proximal and/or distal pH sensor locations. After

GERD medical therapy, CRS symptom

improvement in 25% to 89%. Higher median reflux episodes compared to

the CRS group was higher.

CRS. Suggests that acidic

reflux may not have role in CRS pathogenesis.

controls. Higher abnormal impedance readings compared to 11.1% of controls.

probes in 19/20 surgically

refractory CRS patients and

positive nasal pepsin assays in 5/5 patients tested.

Study Year LOE Study Design Study Groups Clinical Endpoint Conclusions

Mean middle meatal pH in

Rare NPx reflux events in

Positive pharyngeal pH

hypopharynx, proximal and distal esophagus Dual pH-probe testing, laryngoscopy, nasal

endoscopy. Individual sinus symptoms (ISS) and global satisfaction (GS) after 12 weeks of treatment

Intra-nasal middle meatal pH testing

Wong 692 2004 3 Cohort 40 patients with CRS Incidence of PARE with 24 hours 4-sensor probe pH monitoring at NPx,

Reflux questionnaires for both groups, 24 hours

multichannel intraluminal

impedance pH monitoring

NPx tissue biopsy (analyzed for pepsin), dual pH probe testing, probe in NPx and UES

Refractory CRS, post-ESS, (n = 22)

DiBaise 678 2002 3 Cohort CRS patients tested for GERD, subsequently treated with PPI (n = 11). GERD control patients without CRS (n = 19) Katle 685 2017 4 Case Control

50 adult patients with CRS (100 meati)

50 adult controls (100 meati)

46 adult patients with CRS 45 healthy controls

Loehrl 694 2012 4 Case-control

Bhawana 709 2014 4 Case Control

TABLE IX-7 (Continued)