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354

International consensus statement on rhinosinusitis

(Continues)

Richness increased after surgery for most patients, without significant changes in other diversity measures. Samples dominated by Firmicutes, Proteobacteria, Actinobacteria. confusum more prevalent in control population. No Acinetobacter johnsonii and Corynebacterium

SNOT-22 Bacterial profiles dominated by Corynebacterium and Staphylococcus in all 26 patients.

relative abundance in CRS vs control. A. johnsonii associated with improved in SNOT-22 and VAS. Pseudomonas aeruginosa associated with significant

enrichment of Actinobacteria, including Corynebacteria .

prevalent species identified in CRS. S.aureus with increased

negative effect on SNOT-22. Patients with optimal outcomes showed increased diversity measures and

Treatment with doxycycline or prednisone had variable and unpredictable changes.

No bacterial taxa significantly correlated with changes in SNOT-22 scores after treatment.

Groups Clinical Endpoint Conclusions Jain 775 2018 3 Longitudinal study 20CRS patients receiving

CRS 5-symptom score survey

further medical or

surgical intervention

Requirement for

SNOT-22 VAS

doxycycline or

prednisone

6 untreated CRS

23CRS

nocontrol

56CRS

26 control

compared to

patients

23CRS

11 control

Study

TABLE IX-10 Evidence for microbiome disturbance as a contributing factor for CRS Study Year LOE Study Design Jain 770 2017 3 Longitudinal study examining postoperative changes Cleland 772 2016 3 Longitudinal study

Ramakrishnan 741 2015 3 Longitudinal study