xRead - Nasal Obstruction (September 2024) Full Articles

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355

Orlandi et al.

SNOT-22 Corynebacterium and Staphylococcus high

Karunasagar 777 2018 4 Cross-sectional study using molecular SNOT-22 Bacteria detected in all culture-negative cases. Staphylococcus, Enterobacter , Pseudomonas were dominant groups. Lal 778 2017 4 Cross-sectional study 46CRS 11AR 8 control methods comparing culture-negative CRS nocontrol

correlated with lower SNOT-20 scores. Corynebacteria positively correlated with increased symptom severity.

Staphylococcus likely to culture

Study Year LOE Study Design Groups Clinical Endpoint Conclusions Copeland 776 2018 4 Cross-sectional study 21CRS 12 control SNOT-22 Diversity similar among sinuses, with large interpersonal variation. Proteobacteria significantly more abundant in CRS. At genus level only Escherichia was significantly different with higher abundance in CRS. 20CRS

18 OTUs positively correlated with SNOT-22 scores, 9 of which were Escherichia . One OTU negatively correlated with SNOT-22 – Corynebacterium.

SNOT-22 Bacterial diversity significantly reduced in middle compared to inferior meatus in in most patients. CRSsNP patients. MM diversity lower in CRSsNP. Linear regression analysis

based on SNOT-22 scores did not reveal any statistically significant differences for diversity measures.

SNOT-20 CRS patients with decreased diversity compared to controls. 228 groups

even when low abundance.

19CRS

nocontrol

10CRS

10control

Study

Joss 779 2016 4 Cross-sectional study

molecular and

Abreu 737 2012 4 Cross-sectional with secondary

comparing

culture methods

mouse model

TABLE IX-10 (Continued)