xRead - Nasal Obstruction (September 2024) Full Articles

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Orlandi et al.

(Continues)

Innate Immunity Activity Increased

Increased

Decreased

Increased

Increased

Increased

Increased

Increased

Factor B, C3, and C5 mRNAs level were significantly

higher in sinonasal tissue of CRSsNP vs control.

S100A7, A8, and A9 mRNA levels in the nasal tissue were significantly

decreased in CRSsNP.

Lactoferrin mRNA level was higher in CRSsNP compared to controls.

RT-PCR IHC TFF1, TFF3 TFF1 and TFF3 mRNAs and proteins levels were significant higher in

ethmoid tissue of CRSsNP vs control.

RT-PCR IHC Lysozyme Lysozyme protein, but not the mRNA, was increased in patients with CRSsNP vs control. Factor B, C3, C5 C7

significantly increased in CRSsNP compared with control.

RT-PCR IHC SP-A SP-A was increased in CRSsNP vs control. RT-PCR b-defensins 1

Anterior ethmoid tissue ELISA and IHC S100A12 S100A12 was significantly elevated in CRSsNP compared to normal controls.

ELISA C3, C4 Serum C3 level was

Type of Innate Immunity Findings

S100A7, S100A8, S100A9

and 4, cathelicidin and lactoferrin

TABLE IX-13 Summary of studies on altered epithelial innate immunity in CRSsNP Study Year Study Groups (size) Tissue Technique Key Antimicrobial Proteins and Peptides Li 805 2014 CRSsNP (12) CRSwNP (12) Control (7) Sinonasal tissue (CRS) Sinonasal tissue (control) Woods 802 2012 CRSsNP (37) CRSwNP (39) Control (6) Sinus mucosa (CRS) Sinus mucosa (control) Schlosser 803 2010 CRSsNP (7) AFRS (8) Control (6) RT-PCR IHC Cui 804 2009 CRSsNP (72) Blood (CRS) Polypoid/inflamed mucosa (CRSsNP, AFRS) Normal mucosa

qRT-PCR IHC

Epithelial cells from the inferior turbinate Nasal polyps

Uncinate tissue (CRSsNP, control)

Maxillary sinus mucosa (CRSsNP, control)

Ethmoid mucosa (CRSsNP) Polyps (CRSwNP) Sinus tissue (control)

Healthy blood

Abigail 816 2018 CRSsNP (28)

Richer 807 2008 CRSsNP (23)

CRSwNP (18)

Control (21)

Hirschberg 806 2016 CRSsNP (19)

CRSwNP (24)

Control (12)

CRSwNP (95)

Control (110)

Control (10)

CRSwNP (25)

Control (17)

Lee 801 2006 CRSsNP (10)