xRead - Nasal Obstruction (September 2024) Full Articles

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364

International consensus statement on rhinosinusitis

Decreased or Normal

Decreased and Increased

Normal

Decreased

Increased

Innate Immunity Activity

Ethmoid bulla or anterior ethmoid mucosa (CRS, control) qRT-PCR TLR2, TLR9 TLR2 mRNA was decreased in CRSsNP. There were no differences in TLR9 between controls and CRSsNP patients. qRT-PCR IHC

sRAGE levels were increased and mRAGE levels were decreased in CRSsNP

compared to CRSwNP and controls.

IHC TLR9 There were no differences in TLR9 between controls and CRSsNP patients.

proteins levels were lower in CRSsNP compared to controls.

significantly higher in

CRSsNP compared to controls.

Type of Innate Immunity Findings

TLR2 mRNA level was

TLR7, TLR8, TLR9

RT-PCR TLR2, TLR5, TLR6,

TLR2, TLR4, TLR7 TLR2, 4, and 7 mRNAs and sRAGE mRAGE esRAGE

IHC

Study Year Study Groups (size) Tissue Technique

Inflamed sinonasal tissue qRT-PCR Nasal tissue Nasal polyps Ethmoid mucosa (CRSsNP) Polyps (CRSwNP) Sinus tissue (control)

Nasal polyps (CRS)

Nasal tissue (control)

Pattern Recognition Receptors Detwiller 813 2014 CRSsNP (19) CRSwNP (17) Control (9) Zhang 812 2013 CRSsNP (40)

Hirschberg 806 2016 CRSsNP (19)

Van Crombruggen 811 2012 CRSsNP (22) CRSwNP (19) Control (17)

Park 814 2018 CRSsNP (12)

CRSwNP (24)

Control (12)

CRSwNP (38)

Control (23)

CRSwNP (24)

Control (12)

TABLE IX-13 (Continued)