xRead - Nasal Obstruction (September 2024) Full Articles

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365

Orlandi et al.

(Continues)

Normal

Increased

Increased

Increased

Increased

Normal

Increased

Innate

Immunity Activity

TABLE IX-14 Summary of studies on altered non-epithelial innate immunity in CRSsNP Study Year Study Groups (size) Tissue Technique Eosinophils Huang 817 2017 CRSsNP (37) CRSwNP (66) Control (9) Blood FACS Blood eosinophils No significant difference was Takahashi 818 2017 CRSsNP (33) CRSwNP (45) AERD(31) Control (24) Nasal lavage fluids FACS Eosinophils of nasal secretion The eosinophil microparticles Sejima 819 2012 CRSsNP (9) CRSwNP (19) Control (14) Nasal tissue Nasal polyps H&E staining ELISA Tissue eosinophils The number of eosinophils and the level of ECP was significantly increased in Cao 820 2009 CRSsNP (94) CRSwNP (151) Control (50) Nasal tissue Nasal polyps H&E staining IHC Tissue eosinophils No significant difference was Nasal tissue Type of Innate Immunity Findings observed in blood eosinophils between CRSsNP and controls. were significantly increased in CRSsNP compared to controls. CRSsNP compared to controls.

H&E staining ELISA IHC Tissue eosinophils CRSsNP had a significantly higher level of eosinophil cationic protein (eosinophils) compared to controls.

H&E staining ELISA Tissue neutrophils CRSsNP had a significant higher protein level of MPO (neutrophils) compared to controls.

observed in tissue eosinophil

counts between CRSsNP and controls.

H&E staining ELISA IHC Tissue neutrophils CRSsNP had a significant higher protein level of MPO (neutrophils) compared to controls.

Nasal polyps

Nasal tissue

Nasal polyps

Nasal tissue

Nasal polyps

CRSwNP (10)

CF- CRSwNP (13) Control (9)

Sejima 819 2012 CRSsNP (9)

CRSwNP (19)

Control (14)

CRSwNP (10)

CF- CRSwNP (13) Control (9)

VanZele 821 2006 CRSsNP (8)

VanZele 821 2006 CRSsNP (8)

Neutrophils