xRead - Nasal Obstruction (September 2024) Full Articles

20426984, 2021, 3, Downloaded from https://onlinelibrary.wiley.com/doi/10.1002/alr.22741 by Stanford University, Wiley Online Library on [01/07/2024]. See the Terms and Conditions (https://onlinelibrary.wiley.com/terms-and-conditions) on Wiley Online Library for rules of use; OA articles are governed by the applicable Creative Commons License

366

International consensus statement on rhinosinusitis

Normal

Normal

Normal

Normal

Normal

Normal

Normal

Normal

Normal

Innate

Immunity Activity

H&E staining IHC Tissue macrophages There was no significant difference between CRSsNP and controls in terms of the number ofCD68 + cells (macrophages).

H&E staining ELISA IHC Tissue macrophages There was no significant difference between CRSsNP and controls in terms of the number ofCD68 + cells (macrophages). H&E staining TR-PCR FACS Tissue mast cells There was no significant RT-PCR ELISA IHC

observed in fibroblasts between CRSsNP and controls.

observed in basophils between CRSsNP and controls.

difference in mast cells between CRSsNP and controls.

observed in fibroblasts between CRSsNP and controls.

difference in mast cells between CRSsNP and controls.

observed in basophils between CRSsNP and controls.

observed in fibroblasts between CRSsNP and controls.

No significant difference was

Type of Innate Immunity Findings

Tissue mast cells There was no significant

IHC Tissue fibroblast No significant difference was FACS Cell Culture

Tissue fibroblast (FSP + VCAM + cells) No significant difference was

No significant difference was

Tissue basophils No significant difference was

Tissue fibroblast (Vimentin + α -SMA + cells)

Nasal lavage fluids FACS Basophils of nasal secretion IHC

Study Year Study Groups (size) Tissue Technique Macrophages Cao 820 2009 CRSsNP (94) CRSwNP (151) Control (50) Nasal tissue Nasal polyps

H&E

Immunofluorescence FACS RT-PCR

Nasal tissue

Nasal polyps

Nasal tissue

Nasal polyps

Nasal tissue

Nasal polyps

Nasal tissue

Nasal polyps

Nasal tissue

Nasal polyps

Nasal tissue

Nasal polyps

Nasal tissue

Nasal polyps

Shaw 822 2012 CRSsNP (6)

Park 825 2017 CRSsNP (20)

Carroll 826 2016 CRSsNP (22) Oyer 827 2013 CRSsNP (15) CRSwNP (13) Control (24)

Takabayashi 823 2012 CRSsNP (70)

CRSwNP (91)

Control (42)

Takahashi 818 2017 CRSsNP (33)

CRSwNP (45) AERD(13)

Control (24)

CRSwNP (10)

CF- CRSwNP (13) Control (9)

CRSwNP (9)

Control (2)

CRSwNP (16)

NP with AERD (10)

NP without AERD (17) Control (15)

CRSwNP (20)

Control (10)

CRSwNP (6)

Control (13)

VanZele 821 2006 CRSsNP (8)

Mahdavinia 824 2014 CRSsNP (15)

TABLE IX-14 (Continued)

Basophils

Mast cells

Fibroblasts