xRead - Nasal Obstruction (September 2024) Full Articles

20426984, 2021, 3, Downloaded from https://onlinelibrary.wiley.com/doi/10.1002/alr.22741 by Stanford University, Wiley Online Library on [01/07/2024]. See the Terms and Conditions (https://onlinelibrary.wiley.com/terms-and-conditions) on Wiley Online Library for rules of use; OA articles are governed by the applicable Creative Commons License

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Orlandi et al.

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Sinoasal tissue Nasal polyps ELISA Tissue IL-25 IL-25 was not elevated in NPs. Normal Sinoasal tissue Nasal polyps Normal

Innate Immunity Activity Normal

Normal

Normal

Normal

Increased

Increased

RT-PCR Tissue IL-25 There was no significant difference in IL-25 between CRSsNP and controls.

RT-PCR Tissue IL-33 The mRNA level of IL-33 was not increased in CRSsNP.

RT-PCR IHC Tissue IL-25 There was no significant difference in IL-25 between CRSsNP and controls. IHC

RT-PCR IHC Tissue IL-25 IL-25 mRNA level was not increased the CRSwNP group compared to the control . RT-PCR ELISA

RT-PCR IHC Tissue IL-33 There was no significant difference in IL-33 between CRSsNP and controls.

Tissue IL-25 IL-25 mRNA level was significantly higher in the CRSsNP group compared to controls

RT-PCR IHC Tissue IL-33 IL-33 protein level was significantly higher in the CRSsNP group compared to controls.

Type of Innate Immunity Findings

TABLE IX-15 Epithelial-derived innate cytokines in CRS Study Year Study Groups (size) Tissue Technique Il-25 Hong 162 2018 CRSsNP (20) CRSwNP (90) Control (16) Nasal tissue Nasal polyps Ozturan 828 2016 CRSsNP (20) CRSwNP (20)

Nasal tissue

Nasal polyps

Nasal tissue

Nasal polyps

Nasal tissue

Nasal polyps

Sinoasal tissue Nasal polyps

Sinoasal tissue Nasal polyps

Shin 830 2015 CRSsNP (65)

Kim 832 2016 CRSsNP (61)

Xu 829 2016 CRSsNP (65)

CRSwNP (50)

Control (27)

Lam 831 2012 CRSsNP (18)

CRSwNP (12) Control (7)

Hong 162 2018 CRSsNP (20)

CRSwNP (90) Control (16)

Lam 831 2012 CRSsNP (18)

CRSwNP (12) Control (7)

Control (20)

CRSwNP (50)

Control (27)

CRSwNP (166) Control (19)

IL-33