xRead - Nasal Obstruction (September 2024) Full Articles

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370

International consensus statement on rhinosinusitis

Decreased structural epithelial barrier function.

Reduced expression of genes involved in epithelial barrier

maintenance and repair.

Decreased structural epithelial barrier function.

Decreased antimicrobial barrier functions.

Effect on epithelial barrier

Reduced Claudin-1 and Occludin in NP.

Reduction in tight junction protein expression following

cytokine

exposure.

Decreased

S100A7, S100A8.

CRSsNP decreased S100A9. CRSwNP decreased SPINK5.

Occludin, ZO1 Decreased TRR in CRSwNP specimens.

expression of

Occludin and ZO1.

Tieu 871 2010 5 CRS Nasal lavage, mucosa andNP IHC, ELISA S100 Decreased S100 in CRS. Richer 807 2008 5 CRSwNP,

Specific gene targets Findings

CRSw/sNP

Decreased

IHC, Western blot Claudin-1, Occludin

Epithelial cell culture RT-PCR, IHC S100A7, S100A8, S100A9,

SLC9A3R1, SPINK5

resistance, IHC,

Western blotting, RT-PCR

Study Year LoE Study groups Tissue Techniques Soyka 849 2012 5 CRSwNPvs CRSsNP Mucosa, Polyp Trans-tissue

Epithelium

cell culture

Mucosa,

CRSsNP

CRSwNP,

Control

Rogers 855 2011 5 CRSwNP,

TABLE IX-16 (Continued)