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International consensus statement on rhinosinusitis

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IgG3 subclass deficiency is the most common IgG subclass deficiency. The majority of patients treated with Ig responded by

reduction in the frequency of infections and the requirement for antibiotics. Pimenta 930 2019 4 Cross-sectional Patients with hypogammoglob ulinemia; age 16-65; n = 8 Clinical and laboratory characteristics

Stratification of SAD by severity demonstrates a significant increase in the comorbid severity of asthma and infections in CRS patients with

moderate-to-severe SAD compared with those with mild SAD and those without SAD. Walsh 931 2017 4 Case series 27 adults with CVID; 4 adults with SAD; age 18-83 Lund-Mackay scores Frequency sinus & pulmonary infections requiring antibiotics

In patients with hypogammoglobulinemia, the main infections were RS and pneumonia, and airway manifestations prevailed. Keswani 952 2017 4 Case control Adults with CRS; n = 595 Humoral status (Ig levels, antibody titers) Clinical characteristics (Lund-Mackay, endoscopy/CT scores, asthma severity)

Ig replacement therapy has a positive impact on the frequency of RS and pulmonary infections in adult patients with CVID and SAD.

TABLE IX-18 Evidence for immunodeficiency as a contributing factor for CRSsNP Study Year LOE Study Design Study Groups Clinical Endpoint Conclusions Quinti 40 2007 3 Prospective cohort Italian CVID followed for a mean of 11 years; age 2-73; n = 224 Prevalence of CRS, CLD and other co-morbidities in patients with CVID at the time of diagnosis and after IVIG therapy It is possible that both IVIG treatment and better diagnostic and therapeutic strategies have had a great impact on CVID mortality. There is a need to develop international guidelines for the prevention and therapy of CLD, CRS, and other chronic diseases in patients with immunodeficiencies. Khokar 947 2019 4 Case series Adults with primary selective IgG subclass deficiencies; n = 78 Upper and lower respiratory tract infections Proportions and absolute numbers of specific CD-type T cells