xRead - Nasal Obstruction (September 2024) Full Articles

20426984, 2021, 3, Downloaded from https://onlinelibrary.wiley.com/doi/10.1002/alr.22741 by Stanford University, Wiley Online Library on [01/07/2024]. See the Terms and Conditions (https://onlinelibrary.wiley.com/terms-and-conditions) on Wiley Online Library for rules of use; OA articles are governed by the applicable Creative Commons License

375

Orlandi et al.

(Continues)

Patients with CD8 + T lymphocytes lymphopenia express disease similar to patients with conventional CRS. These patients may occasionally benefit from antibacterial therapies.

23.4% of CRS patients with normal IgG levels evaluated for immunodeficiency had SAD. A subset of patients with SAD benefit from Ig replacement. Gabra 953 2014 4 Case control 67 Adult low CD8 + CRS patients; 480 controls with CRSwNP SerumCD8 + T-lymphocyte levels Bacteriology on endoscopically-obtained sinus culture Antibiotic use

Undetectable serum total IgE may serve as a marker of immune dysregulation and autoimmunity.

immunodeficiency in medically resistant CRS. There are also no unique clinical and

demographic characteristic of these patients. Routine screening of major immunoglobulins and IgG subclasses recommended for the group of CRS patients who failed medical treatment. Kashani 946 2015 4 Case series Adults with CRS; n = 239 Quantitative Ig levels Pre- and post-antibody titers toPPV

Patients with medically refractory CRS may have a high prevalence of low preimmunization antipneumococcal titers and SAD.

Study Year LOE Study Design Study Groups Clinical Endpoint Conclusions Odat 936 2016 4 Case control Adults with refractory CRS; n = 257 Measurements of serum IgM, IgA, IgG, and IgG subclasses (compared to matched controls) There is a high prevalence of subtle humoral

Serum total IgE, IgM, IgG and IgG subclasses

Severity of disease as assessed by the need for sinus surgery

Baseline antipneumococcal titers

Functional antipneumococcal response

immunodefi ciency; n = 129

adults with low IgE; matched

controls (1:4)

Adult CRS patients who had ESS and

prior assessment for humoral

226 children and

case control

Carr 943 2011 4 Case series with retrospective review

Magen 935 2014 4 Retrospective

TABLE IX-18 (Continued)