xRead - Nasal Obstruction (September 2024) Full Articles

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International consensus statement on rhinosinusitis

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Immunodeficiency and autoimmune cases present with similar severity of disease when compared with controls with CRS. Patients with immune dysfunction may experience similar benefit from ESS. Cui 804 2009 4 Case control Adult Chinese patients with CRS; n = 277 Quantitative serum Ig Serum mannose-binding lectin levels

recurrent/severe infections may benefit from Ig treatment particularly in the presence of

impaired pneumococcal antibody responses.

Low serum IgE levels was not associated with CRS. Seppanen 937 2006 4 Case control 48 CRS or RARS patients; 50 ARS patients; healthy controls; age 18-83 Serum Ig levels Plasma C3/C4 levels

Ig and mannose-binding lectin deficiencies are not associated with CRS. Yel 927 2009 4 Case control Adults with IgM deficiency; age 39-79; n = 374 Serum Ig and IgG subclass levels Pneumococcal antibody titers Lymphocyte response to mitogens and antigens IgM-deficient patients who present with Bondioni 928 2007 4 Case series 27 patients with CVID, 18 patients with agamma globulinemia CT evidence of CRS

CT evidence of bronchiectasis Pulmonary CT findings do not correlate with severity of sinus involvement. Levin 934 2006 4 Cross-sectional Adult pregnant women; n = 662 Serum total IgE levels in patients with CRS

Multiple clinical and immunological parameters may need to be evaluated when searching for prognostic variables in patients with CRS and RARS.

humoral immune dysfunction in patients with refractory CRS. An assessment of immune function should be undertaken routinely in

refractory CRS, which should include serum Ig levels. If these are normal, then functional antibody responses may be performed. Khalid 954 2010 4 Case control 22 patients with CRS associated immune dysfunction; 22 controls with CRS Preoperative CT findings Pre-/postoperative endoscopic findings Disease-specific QoL

Study Year LOE Study Design Study Groups Clinical Endpoint Conclusions Alqudah 941 2010 4 Case series with retrospective review Refractory CRS patients who had prior ESS; age 22-77; n = 67 Quantitative Ig levels IgG subclass levels Functional antipneumococcal antibody response There is an unexpectedly high prevalence of

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