xRead - Nasal Obstruction (September 2024) Full Articles

20426984, 2021, 3, Downloaded from https://onlinelibrary.wiley.com/doi/10.1002/alr.22741 by Stanford University, Wiley Online Library on [01/07/2024]. See the Terms and Conditions (https://onlinelibrary.wiley.com/terms-and-conditions) on Wiley Online Library for rules of use; OA articles are governed by the applicable Creative Commons License

384

International consensus statement on rhinosinusitis

TABLE IX-22 Evidence for viruses as a contributing factor for CRS Study Year LOE Study Design Study Groups Clinical Endpoint Conclusions Goggin 754 2019 3* Case-control Healthy controls, CRSwNP, CRSsNP Viral presence, Lund-Mackay & Lund-Kennedy scores, symptom scores Viral positivity significantly greater in CRSsNP; Objective scores significantly worse in virus ( + ) compared to virus (-) CRSsNP; RV, coronavirus, and influenza were isolated. Hwang 1012 2019 4 Case-control Healthy controls, CRSwNP, CRSsNP

(Continues)

Viral presence; IFN- β andgamma No difference in viral rates between control and CRS; decreased expression of IFN- β and gamma in

RV prevalence 29%; RSV 12% Higher than expected prevalence for rhinovirus.

Divekar 1010 2015 4 Case-control Adults 43% in CRSwNP; 55% in control No statistically significant difference. Hardjojo 367 2015 4 Case-control Infants separated into prolonged/recurrent rhinitis vs typical duration RV incidence: 14% in rhinitis group; 13% in control No significant difference between groups.

CRS, but no data regarding effect of viral infection.

Goggin 1013 2018 4 Case-control Adult controls and adults Viral presence Virus present in 75% of patients; poor correlation between inferior and middle meatus. Abshirini 1007 2015 4 Cross-sectional Adults undergoing ESS for CRSwNP or CRSsNP with CRSwNP or CRSsNP

24% viral recovery from CRS group; 0% from controls.

Lee 1016 2015 4 Case-control Adults 36% RV in CRS; 21% in control Lima 1008 2015 4 Cross-sectional Adults 19% prevalence of RV in CRS patients Rowan 753 2015 4 Case-control Healthy controls, CRSwNP, CRSsNP Viral presence, Lund-Mackay & Lund-Kennedy scores, symptom scores