xRead - Nasal Obstruction (September 2024) Full Articles

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385

Orlandi et al.

Healthy, CF, COPD - inferior surface of middle turbinate IFN- β , IFN- γ , il-6, IL-8 Significant change after rhinovirus inoculation. Lee 1019 2016 5 Murine model; rhinovirus challenge Murine model of chronic allergic RS IL-6, MIP-2, IL -13, TNF- α , IFN- γ Kim 386 2015 5 Invitro rhinovirus challenge

Cho 1006 2013 4 Case-control Adults and children PCR for virus detection; 44% RV in CRSwNP; 20% in control Wood 1011 2011 4 Case-control Adults with CRS and controls undergoing sinus surgery Presence of respiratory viruses No viruses detected by PCR. Essaidi- 383 Laziosi 2017 5 Invitro rhinovirus challenge Alves 385 2016 5 Invitro rhinovirus Rhinovirus 2x more prevalent in CRSwNP than control.

Rhinovirus more likely to be isolated fromCRS.

Healthy control, CRS at inferior turbinate IL-6, IL-8, IFN- β Significant change after rhinovirus inoculation. Nakagome 1017 2014 5 Invitro rhinovirus challenge Undergoing ESS - residual epithelial tissue CCL, CXCL8/10/11, IFN- α 2, IFN- β , IFN-L1, and IL-6

No significant difference between groups.

Significant change after rhinovirus inoculation.

Study Year LOE Study Design Study Groups Clinical Endpoint Conclusions

Jang 1015 2006 4 Case-control Adults 21% RV prevalence in CRS; 0% in control IL-8, rantes, IP-10, IFN γ , IL -1, IL -6, GM-CSF challenge

Liao 1009 2014 4 Case-control Adults PCR detection of viruses; RV 36% for CRSwNP; 28% for CRSsNP; 49% in control

Healthy controls; nasal polyp epithelium

TABLE IX-22 (Continued)

*case-control study, but upgraded due to including radiographic, endoscopic, and symptom data as well as viral detection, with larger sample size