xRead - Nasal Obstruction (September 2024) Full Articles

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TABLE X-8 Evidence for vitamin D3 deficiency as a contributing factor for CRSwNP Study Year LOE Study Design Study Groups Clinical Endpoint Conclusions Habibi 725 2019 4 Case-Control 50Control 35CRSsNP 32CRSwNP Serum 25VD3 level Serum 25VD3 significantly lower in CRSwNP compared to controls. Wang 713 2019 4 Retrospective Case-Control 21Control 42CRSwNP 25CRSsNP Serum 25VD3 SNOT22 Lund-Mackay score Serum 25VD3 lower in CRSwNP. Serum 25VD3 level inversely associated with SNOT22 in CRSwNP. Christensen 724 2017 4 Case-control 13Control 8CRSsNP 10CRSwNP Sinonasal Vitamin D Receptor gene expression level Sinonasal CYP2R1, CYP27B1, CYP24A1 gene expression levels No difference in VDR expression between CRSwNP and controls. CYP27B1 gene expression lower in CRSwNP compared to controls. CYP24A1 upregulated in CRSwNP compared to controls. Konstantinidis 714 2017 4 Case-Control 32Control 30CRSsNP 32CRSwNP 31CFsNP 27CFwNP Serum 25VD3 Lund-Kennedy score Lund-Mackay score Lower serum 25VD3 in CRSwNP and CFwNP. 25VD3 inversely correlated with Lund-Kennedy and Lund-Mackay scores in CRS andCF. Carroll 1417 2016 4 Case-Control 12 Control (CSF leak/pituitary tumor patients) 15CRSwNP HSNF proliferation VD3 deficiency associated with increased HSNF proliferation in CRSwNP. When treated with 1,25VD3, there was a significant decrease in HNSF proliferation in CRSwNP but not control patients.