xRead - Nasal Obstruction (September 2024) Full Articles

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Orlandi et al.

(Continues)

Innate Immunity Activity Increased

Normal

Decreased

Increased

Increased

Normal

Increased

Increased

mRNA and proteins levels in ethmoid tissue of CRSwNP and control.

Immunofluorescence staining AMCase, ChT AMCase was increased in nasal tissue of CRSwNP. RT-PCR IHC SP-A SP-A was increased in sinonasal tissue of CRSwNP.

Anterior ethmoid tissues ELISA and IHC S100A12 S100A 12 was significantly elevated in CRSwNP compared to normal controls.

lactoferrin proteins were decreased in CRSwNP

tissues compared to that of CRSsNP and controls.

cathelicidin and lactoferrin

mRNA level were higher in CRSwNP compared to controls.

Nasal polyps Nasal tissue (control) ELISA SP-A, SP-D No difference in SP-A and SP-D between 2 groups. Nasal tissue (CRS) Nasal tissue (control) Microarray RT-PCR ELISA IHC PLUNC1, PLUNC2, Lactoferrin

RT-PCR IHC Lysozyme Lysozyme protein, but not the mRNA, was increased in patients with CRSwNP.

PLUNC 1, PLUNC 2, and

RT-PCR IHC TFF1, TFF3 Similar TFF1 and TFF3

Type of Innate Immunity Findings

Beta-defensins 1 and 4,

RT-PCR beta-defensins 1 and 4, cathelicidin and lactoferrin

TABLE X-11 Summary of studies on altered innate immunity in CRSwNP Study Year Study Groups Tissue Technique Key Antimicrobial Proteins and Peptides Abigail 816 2018 CRSsNP (28) CRSwNP (25) Control (17) Hirschberg 806 2016 CRSsNP (19) CRSwNP (24) Control (12) Ethmoid mucosa (CRSsNP) Polyps (CRSwNP) Sinus tissue (control)

Sinonasal tissue (CRS)

Sinonasal tissue (control)

tissue (control) Nasal polyps

Sinus mucosa (CRS, control)

Nasal polyps IT

Nasal tissue (control)

Woods 802 2012 CRSsNP (37)

CRSwNP (12) Control (7)

Seshadri 870 2012 CRSsNP (59)

CRSwNP (81)

Control (48)

Park 1482 2011 CRSwNP (202) Control (11).

Control (15)

CRSwNP (39) Control (6)

Control

Salman 1481 2012 CRSwNP (21)

Li 805 2014 CRSsNP (12)

Wang 1483 2010 CRSwNP