xRead - Nasal Obstruction (September 2024) Full Articles

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470

International consensus statement on rhinosinusitis

(Continues)

Decreased

Increased or normal

Increased

Innate Immunity Activity Increased

Increased

Increased

Normal

TLR9, HBD-2, and SP-A were decreased in nasal tissue of recalcitrant CRSwNP.

HBD-2 was increased in CF-CRSwNP vs

Non-CF-CRSsNP and control.

TLR2 was detected between non-CF-CRSwNP and control.

significantly increased in nasal tissue of CRSwNP.

ELISA C3, C4 Serum C3 level was increased inCRSwNP. RT-PCR ELISA TLR9, HBD-2 SP-A

increased in nasal tissue of CRSwNP.

increased in CRSwNP.

No difference was seen in nasal tissue among CRSwNP and control groups.

RT-PCR IHC LL-37 LL37 was significantly RT-PCR Western blot IHC SP-A, SP-B, SP-C, SP-D

No difference in TLR2 and

SP-B protein level was

RT-PCR AMCase AMCase mRNA level was RT-PCR ELISA HBD-2, HBD-3 TLR2, TLR4

Type of Innate Immunity Findings

HBD-2, HBD-3 TLR2, TLR4

Study Year Study Groups Tissue Technique

Flow cytometry

RT-PCR IHC

isolated from sinus mucosa tissue

Sinonasal sample (CRS)

IT mucosa (control) Nasal mucosa (CRSwNP)

Nasal mucosa (control)

(CRSwNP, control)

Turbinate mucosa (control)

Epithelial cell

IT tissue (control)

Blood (CRS)

Healthy blood

Ethmoid mucosa

Nasal polyps

Nasal polyps

Claeys 1489 2003 Tonsillar disease

Cui 804 2009 CRSsNP (72) Ramanathan 1484 2008 CRSwNP (32) CRSwNP (95) Control (110)

Control (10)

Claeys 1486 2005 CF-CRSsNP (14)

Non-CF-CRSwNP (15) Control (10)

Control (7) AR

Control

Control (11)

Hypertrophic adenoids Sinonasal disease

Ramanathan 1485 2006 CRSwNP (22)

Chen 1487 2004 CRSwNP (12)

Schicht 1488 2004 CRSwNP

TABLE X-11 (Continued)