xRead - Nasal Obstruction (September 2024) Full Articles

20426984, 2021, 3, Downloaded from https://onlinelibrary.wiley.com/doi/10.1002/alr.22741 by Stanford University, Wiley Online Library on [01/07/2024]. See the Terms and Conditions (https://onlinelibrary.wiley.com/terms-and-conditions) on Wiley Online Library for rules of use; OA articles are governed by the applicable Creative Commons License

471

Orlandi et al.

Innate Immunity Activity Increased

Decreased

Increased

Decreased or normal

Increased

Increased

Increased

Decreased

Decreased

IHC TLR9 TLR9 protein level was higher in CRSwNP compared to controls.

were decreased in CRSwNP compared to controls.

level were increased in NPs ofCRSwNP.

remarkably decreased in CRSwNP.

TLR2, 5, 6, 7, 8, and 9 mRNA level were higher in CRSwNP compared to controls.

RT-PCR IHC TLR2, TLR4, TLR7 TLR2, TLR4, TLR7, and IL-4 were increased in CRSwNP patients when compared with either CRSsNP qRT-PCR IHC sRAGE mRAGE esRAGE

patients or control subjects.

NLR mRNA level was higher in NPs than in normal nasal mucosa.

isolated from nasal tissue Flow cytometry TLR9 TLR9 epithelial cell isolated from nasal tissue was

remarkably decreased in CRSwNP.

TLR9 TLR9 in epithelial cells from nasal mucosa was remarkably decreased in CRSwNP.

sRAGE and mRAGE levels

TLR-9 mRNA and protein

TLR2 in nasal tissue was

Type of Innate Immunity Findings

signaling pathways

TLR4, TLR5, TLR6,

TLR7, TLR8, TLR9, TLR10

TLR7, TLR8, TLR9,

125 genes for TLRs

RT-PCR TLR1, TLR2, TLR3,

RT-PCR TLR2, TLR5, TLR6,

NOD1, NOD2, NALP3

Study Year Study Groups Tissue Technique

DNA microarray RT-PCR

Western Blot IHC

RT-PCR IHC

RT-PCR

Flow cytometry

Inflamed sinonasal tissue

Nasal polyps (CRS) Turbinate tissue (control)

Inferior turbinate tissue (control)

Ethmoid mucosa (CRSsNP)

isolated from

mucosal tissue

Nasal tissue

Nasal polyps

Nasal polyps

Polyps (CRSwNP)

Sinus tissue (control)

Nasal polyps (CRS)

Nasal tissue (control)

Nasal polyps

Nasal tissue (control)

Epithelial cell

Epithelial cell

Pattern Recognition Receptors Park 814 2018 CRSsNP (12) CRSwNP (24) Control (12) Zhang 812 2013 CRSsNP (40) CRSwNP (38) Control (23)

Van Crombruggen 811 2012 CRSsNP (22) CRSwNP (19) Control (17)

Zhao 1491 2011 CRSwNP (20) Control (15)

Control (10)

Ramanathan 1494 2006 CRSwNP (10) Hirschberg 806 2016 CRSsNP (19) Control (5)

CRSwNP (24)

Control (12)

Control (10)

Control (10)

Månsson 1490 2011 CRSwNP (24)

Xia 1492 2008 CRSwNP (10)

Lane 1493 2006 CRSwNP (30)

TABLE X-11 (Continued)