xRead - Nasal Obstruction (September 2024) Full Articles

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International consensus statement on rhinosinusitis

(Continues)

Increased or normal

Increased or normal

Increased or normal

Increased

Increased

Increased

Increased

Innate

Immunity Activity

Increased

significant increased number of neutrophils compared with no refractory disease control.

Blood CBA Blood eosinophils The number of blood eosinophils was significant increased in CRSwNP compared to controls.

The eosinophils microparticles were significantly increased in CRSwNP compared to controls.

Serum specimens Cell counts Blood eosinophils The number of blood eosinophils was significant increased in CRSwNP compared to controls.

CRSwNP (66) Control (9) Blood FACS Blood eosinophils The number of blood eosinophils was significantly increased in atopic CRSwNP, but not non-atopic CRSwNP, compared to controls. CRSwNP (45) AER(31) Nasal lavage fluids FACS Eosinophils of nasal secretion IHC

H&E staining IHC Blood eosinophils The number of blood eosinophils was significantly increased in moderate to severe

eosinophilic CRSwNP, but not mild eosinophilic CRSwNP, compared to controls.

H&E staining IHC Tissue eosinophils The number of eosinophils was significantly increased in

eosinophilic CRSwNP, but not mild eosinophilic CRSwNP, compared to controls.

Tissue eosinophils The number of eosinophils was significantly increased in CRSwNP (eosinophilic and non- eosinophilic).

Immunofluorescence analysis Tissue eosinophils Refactory CRSwNP had a

Type of Innate Immunity Findings

TABLE X-12 Summary of studies on altered non-epithelial innate immunity in CRSwNP Study Year Study Groups (size) Tissue Technique Eosinophils Du 1464 2020 CRSwNP (30) Control (10) Gion 1472 2020 CRSsNP (14) CRSwNP (57) Control (13) Nasal tissue Nasal polyps Kim 1463 2020 Refractory CRSwNP (54) Disease control (76) Nasal polyps IHC Nagata 1461 2019 ECRS (22)

RE-PCR

Sinonasal tissue Nasal polyps

Nasal tissue

Nasal polyps

Non-Eosinophilic CRSwNP (16) Control (8)

Baba 1460 2015 Eosinophilic CRSwNP (15)

nECRS (11)

Control (6)

Huang 817 2017 CRSsNP (37)

Veloso-Teles 1462 2019 CRSwNP (37)

Control (34)

Takahashi 818 2017 CRSsNP (33)

Control (24)