xRead - Nasal Obstruction (September 2024) Full Articles

20426984, 2021, 3, Downloaded from https://onlinelibrary.wiley.com/doi/10.1002/alr.22741 by Stanford University, Wiley Online Library on [01/07/2024]. See the Terms and Conditions (https://onlinelibrary.wiley.com/terms-and-conditions) on Wiley Online Library for rules of use; OA articles are governed by the applicable Creative Commons License

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Orlandi et al.

(Continues)

Increased

Increased

Increased

Innate

Immunity Activity

Increased

Increased

Increased

Normal

Tissue eosinophils CRSwNP had a significant increased number of

eosinophils compared to controls.

H&E staining IHC Tissue eosinophils The number of eosinophils was significant increased in CRSwNP compared to controls.

H&E staining ELISA IHC Tissue eosinophils The level of eosinophil cationic protein (eosinophils) was significantly higher in CRSwNP compared to controls.

Tissue eosinophils The number of blood eosinophils was significant increased in CRSwNP compared to controls.

H&E staining ELISA Tissue eosinophils The number of eosinophils was significantly increased in CRSwNP.

H&E staining IHC Tissue eosinophils Both western and Asian CRSwNP had a significant increased number of eosinophils compared to controls.

H&E staining IHC ELISA Tissue eosinophils Tissue eosinophils in NP tissue from China, as measured by

ECP and cytokine/chemokine levels (IL-5 and eotaxin), was

not significantly different from control tissue and was

significantly lower in terms of numbers of eosinophils

compared with polyps from white subjects.

Type of Innate Immunity Findings

ELISA

IHC

FACS

Study Year Study Groups (size) Tissue Technique Mahdavinia 824 2014 CRSsNP (15) CRSwNP (16) Nasal tissue Nasal polyps IHC H&E staining

Nasal tissue

Nasal polyps

Nasal tissue

Nasal polyps

Nasal tissue

Nasal polyps

Nasal tissue

Nasal polyps

Nasal tissue

Nasal polyps

Nasal tissue

Nasal polyps

Sejima 819 2012 CRSsNP (9)

NP with AERD (10)

NP without AERD (17) Control (15)

CRSwNP (19)

Control (14)

Belgian control subjects (21) CRSwNP (10)

South Chinese CRSwNP (29) South Chinese control (29) CF- CRSwNP (13) Control (9)

Zhang 1465 2006 CRSwNP (27) Control (9)

Wen 1459 2012 CRSwNP (187) Control (45)

Cao 820 2009 CRSsNP (94)

CRSwNP (151) Control (50)

VanZele 821 2006 CRSsNP (8)

Zhang 1375 2008 Belgian CRSwNP (26)

TABLE X-12 (Continued)