xRead - Nasal Obstruction (September 2024) Full Articles

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474

International consensus statement on rhinosinusitis

(Continues)

Normal

Increased

Increased

Increased

Normal

Increased

Normal

Innate

Immunity Activity

Increased

Increased

Tissue neutrophils CRSwNP had a significant increased number of neutrophils.

H&E staining ELISA Tissue neutrophils CRSwNP had a significant higher protein level of MPO (neutrophils). FACS Tissue neutrophils CRSwNP had a significant increased number of neutrophils.

H&E staining IHC Tissue neutrophils Both western and Asian CRSwNP have a significant increased number of neutrophils.

H&E staining IHC ELISA Tissue neutrophils No significant difference was observed between CRSwNP and controls.

Blood CBA Blood neutrophils No significant difference was observed between CRSwNP and controls. Nasal polyps IHC

significant increased number of neutrophils compared with no refractory disease control.

Serum specimens Cell counts Blood neutrophils No significant difference was observed between CRSwNP and controls. Nasal tissue Nasal polyps ELISA IHC

significant higher protein level of MPO (neutrophils).

Immunofluorescence analysis Tissue neutrophils Refractory CRSwNP had a RT-PCR IHC ELISA

Type of Innate Immunity Findings

H&E staining ELISA IHC Tissue neutrophils CRSwNP (CF-NP) had a

Study Year Study Groups (size) Tissue Technique Neutrophils Du 1464 2020 CRSwNP (30)

Nasal tissue

Nasal polyps

Nasal tissue

Nasal polyps

Nasal tissue

Nasal polyps

Nasal tissue

Nasal polyps

Nasal tissue

Nasal polyps

Kim 1463 2020 Refractory CRSwNP (54) Disease control (76)

Veloso-Teles 1462 2019 CRSwNP (37)

Control (34)

Wen 1459 2012 CRSwNP (187) Control (45)

Belgian control subjects (21) CRSwNP (10)

South Chinese CRSwNP (29) South Chinese control (29) CF- CRSwNP (13) Control (9)

Control (10)

Cao 1495 2019 CRSwNP (22)

Control (15)

Sejima 819 2012 CRSsNP (9)

CRSwNP (19)

Control (14)

Zhang 1375 2008 Belgian CRSwNP (26)

Zhang 1465 2006 CRSwNP (27) Control (9)

VanZele 821 2006 CRSsNP (8)

TABLE X-12 (Continued)