xRead - Nasal Obstruction (September 2024) Full Articles

20426984, 2021, 3, Downloaded from https://onlinelibrary.wiley.com/doi/10.1002/alr.22741 by Stanford University, Wiley Online Library on [01/07/2024]. See the Terms and Conditions (https://onlinelibrary.wiley.com/terms-and-conditions) on Wiley Online Library for rules of use; OA articles are governed by the applicable Creative Commons License

475

Orlandi et al.

(Continues)

H&E staining IHC FACS Tissue macrophages The number of CD68 + CD163 + alternatively activated (M2) macrophages was increased in eosinophilic polyps. Increased H&E staining IHC number of macrophages. Increased H&E staining ELISA IHC Normal

Normal

Increased

Increased

Increased

Innate

Immunity Activity

Increased

difference between CRSwNP and control in terms of the number CD68 + cells (macrophages).

H&E staining IHC Tissue mast cells No significant difference was observed between CRSwNP and controls. IHC Tissue mast cells (IgD + )

Tissue mast cells The number of mast cells were significantly increased in

CRSwNP (Eos and Non-Eos) compared to control.

Tissue mast cells The mast cells were significantly increased in NP compared to control.

The mast cells were significantly increased in Eos CRSwNP compared to control.

H&E staining TR-PCR FACS Tissue mast cells The mast cells were significantly increased in NP compared to control. TR-PCR ELISA IHC

Type of Innate Immunity Findings

Tissue macrophages There was no significant

Tissue macrophages CRSwNP have a significant

Immunofluorescence FACS H&E staining IHC

Immunofluorescence

Study Year Study Groups (size) Tissue Technique Macrophages Nasal tissue

Nasal polyps

Nasal tissue

Nasal polyps

Nasal tissue

Nasal polyps

Nasal tissue

Nasal polyps

Nasal tissue

Nasal polyps

Nasal tissue

Nasal polyps

Nasal tissue

Nasal polyps

Nasal tissue

Nasal polyps

Zhai 1496 2018 Eos CRSwNP (23)

Shaw 822 2012 CRSsNP (6)

non-eosinophilic CRSwNP (41) Control (20) CRSwNP (151) Control (50)

Non-Eos CRSwNP (21) Control (23)

CRSwNP (9)

Control (2)

Yao 1470 2017 Eosinophilic CRSwNP (34) Cao 820 2009 CRSsNP (94)

VanZele 821 2006 CRSsNP (8)

CRSwNP (10)

CF- CRSwNP (13) Control (9)

Gion 1472 2020 CRSsNP (14)

CRSwNP (57)

Control (13)

Baba 1497 2017 Eos CRSwNP (17)

Non-Eos CRSwNP (17) Control (7)

Takabayashi 823 2012 CRSsNP (70)

CRSwNP (91)

Control (42)

TABLE X-12 (Continued)

MastCells